Outcomes and Prognostic Factors in Pediatric Oligodendroglioma: A Population-Based Study

Nicholas J. Goel, Kalil G. Abdullah, Shih Shan Lang

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background/Aims: Pediatric oligodendroglioma (pODG) is a rare primary brain tumor that remains poorly understood. Demographics, outcomes, and prognostic factors were analyzed in 346 pODG cases from the Surveillance, Epidemiology, and End Results database. Methods: Gender, race, age, tumor location, tumor size, tumor grade, extent of resection, and use of radiotherapy were evaluated with respect to overall survival (OS) by univariate and multivariate analysis. These factors were assessed in the pediatric cohort and 5,753 adult oligodendroglioma cases for comparison. Results: The mean OS in pODG was 199.6 months. Five- and 10-year survival rates were 85 and 81%. pODG arose less frequently in the frontal lobe than adult tumors (53 vs. 22%) but was more common in the temporal lobe (32 vs. 18%) and extracortical regions (19 vs. 5%, p < 0.0001). pODG presented with smaller size (55 vs. 24%, p < 0.0001) and lower grade (72 vs. 54%, p < 0.0001) than adult tumors. Tumor location, size, grade, use of radiotherapy, and extent of resection were significant prognostic factors. Size and grade were much stronger prognostic factors in children than adults. While children with oligodendroglioma survive much longer than adults on the whole, there was no difference in outcome between children with high-grade tumors and adults with high-grade tumors. Conclusion: pODG differs significantly from adult oligodendroglioma along a number of demographic and tumor factors at a population level, and key prognostic factors influence survival differently in pODG than in adult disease.

Original languageEnglish (US)
Pages (from-to)24-35
Number of pages12
JournalPediatric Neurosurgery
Volume53
Issue number1
DOIs
StatePublished - Dec 1 2017
Externally publishedYes

Fingerprint

Oligodendroglioma
Pediatrics
Population
Neoplasms
Radiotherapy
Demography
Frontal Lobe
Temporal Lobe
Survival Analysis
Brain Neoplasms
Epidemiology
Multivariate Analysis
Survival Rate
Databases

Keywords

  • Pediatric cancer
  • Pediatric oligodendroglioma
  • Surveillance, Epidemiology, and End Results database

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

Cite this

Outcomes and Prognostic Factors in Pediatric Oligodendroglioma : A Population-Based Study. / Goel, Nicholas J.; Abdullah, Kalil G.; Lang, Shih Shan.

In: Pediatric Neurosurgery, Vol. 53, No. 1, 01.12.2017, p. 24-35.

Research output: Contribution to journalArticle

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abstract = "Background/Aims: Pediatric oligodendroglioma (pODG) is a rare primary brain tumor that remains poorly understood. Demographics, outcomes, and prognostic factors were analyzed in 346 pODG cases from the Surveillance, Epidemiology, and End Results database. Methods: Gender, race, age, tumor location, tumor size, tumor grade, extent of resection, and use of radiotherapy were evaluated with respect to overall survival (OS) by univariate and multivariate analysis. These factors were assessed in the pediatric cohort and 5,753 adult oligodendroglioma cases for comparison. Results: The mean OS in pODG was 199.6 months. Five- and 10-year survival rates were 85 and 81{\%}. pODG arose less frequently in the frontal lobe than adult tumors (53 vs. 22{\%}) but was more common in the temporal lobe (32 vs. 18{\%}) and extracortical regions (19 vs. 5{\%}, p < 0.0001). pODG presented with smaller size (55 vs. 24{\%}, p < 0.0001) and lower grade (72 vs. 54{\%}, p < 0.0001) than adult tumors. Tumor location, size, grade, use of radiotherapy, and extent of resection were significant prognostic factors. Size and grade were much stronger prognostic factors in children than adults. While children with oligodendroglioma survive much longer than adults on the whole, there was no difference in outcome between children with high-grade tumors and adults with high-grade tumors. Conclusion: pODG differs significantly from adult oligodendroglioma along a number of demographic and tumor factors at a population level, and key prognostic factors influence survival differently in pODG than in adult disease.",
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AB - Background/Aims: Pediatric oligodendroglioma (pODG) is a rare primary brain tumor that remains poorly understood. Demographics, outcomes, and prognostic factors were analyzed in 346 pODG cases from the Surveillance, Epidemiology, and End Results database. Methods: Gender, race, age, tumor location, tumor size, tumor grade, extent of resection, and use of radiotherapy were evaluated with respect to overall survival (OS) by univariate and multivariate analysis. These factors were assessed in the pediatric cohort and 5,753 adult oligodendroglioma cases for comparison. Results: The mean OS in pODG was 199.6 months. Five- and 10-year survival rates were 85 and 81%. pODG arose less frequently in the frontal lobe than adult tumors (53 vs. 22%) but was more common in the temporal lobe (32 vs. 18%) and extracortical regions (19 vs. 5%, p < 0.0001). pODG presented with smaller size (55 vs. 24%, p < 0.0001) and lower grade (72 vs. 54%, p < 0.0001) than adult tumors. Tumor location, size, grade, use of radiotherapy, and extent of resection were significant prognostic factors. Size and grade were much stronger prognostic factors in children than adults. While children with oligodendroglioma survive much longer than adults on the whole, there was no difference in outcome between children with high-grade tumors and adults with high-grade tumors. Conclusion: pODG differs significantly from adult oligodendroglioma along a number of demographic and tumor factors at a population level, and key prognostic factors influence survival differently in pODG than in adult disease.

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