TY - JOUR
T1 - Outcomes of COVID-19 in solid organ transplant recipients
T2 - A matched cohort study
AU - Pereira, Marcus R.
AU - Arcasoy, Selim
AU - Farr, Maryjane A.
AU - Mohan, Sumit
AU - Emond, Jean C.
AU - Tsapepas, Demetra S.
AU - Shi, Qiuhu
AU - Purpura, Lawrence
AU - Uhlemann, Anne Catrin
AU - Zucker, Jason
AU - Verna, Elizabeth C.
N1 - Publisher Copyright:
© 2021 Wiley Periodicals LLC
PY - 2021/8
Y1 - 2021/8
N2 - Whether solid organ transplant (SOT) recipients are at increased risk of poor outcomes due to COVID-19 in comparison to the general population remains uncertain. In this study, we compared outcomes of SOT recipients and non-SOT patients hospitalized with COVID-19 in a propensity score matched analysis based on age, race, ethnicity, BMI, diabetes, and hypertension. After propensity matching, 117 SOT recipients and 350 non-SOT patients were evaluated. The median age of SOT recipients was 61 years, with a median time from transplant of 5.68 years. The most common transplanted organs were kidney (48%), followed by lung (21%), heart (19%), and liver (10%). Overall, SOT recipients were more likely to receive COVID-19 specific therapies and to require ICU admission. However, mortality (23.08% in SOT recipients vs. 23.14% in controls, P =.21) and highest level of supplemental oxygen (P =.32) required during hospitalization did not significantly differ between groups. In this propensity matched cohort study, SOT recipients hospitalized with COVID-19 had similar overall outcomes as non-SOT recipients, suggesting that chronic immunosuppression may not be an independent risk factor for poor outcomes in COVID-19.
AB - Whether solid organ transplant (SOT) recipients are at increased risk of poor outcomes due to COVID-19 in comparison to the general population remains uncertain. In this study, we compared outcomes of SOT recipients and non-SOT patients hospitalized with COVID-19 in a propensity score matched analysis based on age, race, ethnicity, BMI, diabetes, and hypertension. After propensity matching, 117 SOT recipients and 350 non-SOT patients were evaluated. The median age of SOT recipients was 61 years, with a median time from transplant of 5.68 years. The most common transplanted organs were kidney (48%), followed by lung (21%), heart (19%), and liver (10%). Overall, SOT recipients were more likely to receive COVID-19 specific therapies and to require ICU admission. However, mortality (23.08% in SOT recipients vs. 23.14% in controls, P =.21) and highest level of supplemental oxygen (P =.32) required during hospitalization did not significantly differ between groups. In this propensity matched cohort study, SOT recipients hospitalized with COVID-19 had similar overall outcomes as non-SOT recipients, suggesting that chronic immunosuppression may not be an independent risk factor for poor outcomes in COVID-19.
KW - COVID-19
KW - transplant
KW - viral infections
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UR - http://www.scopus.com/inward/citedby.url?scp=85107016959&partnerID=8YFLogxK
U2 - 10.1111/tid.13637
DO - 10.1111/tid.13637
M3 - Article
C2 - 33993630
AN - SCOPUS:85107016959
SN - 1398-2273
VL - 23
JO - Transplant Infectious Disease
JF - Transplant Infectious Disease
IS - 4
M1 - e13637
ER -