Outcomes of Heart Transplantation in Adult Congenital Heart Disease With Prior Intracardiac Repair

Atsushi Kainuma, Joseph Sanchez, Yuming Ning, Paul A. Kurlansky, Kelly Axsom, Maryjane Farr, Gabriel Sayer, Nir Uriel, Hiroo Takayama, Yoshifumi Naka, Koji Takeda

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Background: The number of patients with adult congenital heart disease (ACHD) who require orthotopic heart transplantation has increased rapidly in the past 2 decades. This study examined heart transplant outcomes of patients with ACHD who had previous cardiac surgery by using data from the United Network for Organ Sharing database. Methods: Between January 2008 and March 2019, patients with ACHD who underwent previous cardiac surgery and subsequent heart transplantation were identified from the United Network for Organ Sharing database. As a control group, adult patients without congenital heart disease who had previous sternotomy and subsequent heart transplantation were extracted from the database. Propensity score matching was then used to compare outcomes between the 2 groups. Results: There were 793 patients in the ACHD group and 8400 patients in the control group. Among well-matched groups of 486 patients each, 30-day mortality (8.2% vs 3.9%; P = .004) and perioperative need for dialysis (22.7% vs 13.3%; P < .001) were significantly higher in the ACHD group compared with the control group. However, there was no difference in 10-year survival between the groups (ACHD 66.0% vs control 64.1%; log-rank P = .353). Conclusions: Compared with well-matched patients without ACHD but with previous sternotomy, patients with ACHD and previous intracardiac repair had a higher operative risk but similar 10-year survival.

Original languageEnglish (US)
Pages (from-to)846-853
Number of pages8
JournalAnnals of Thoracic Surgery
Volume112
Issue number3
DOIs
StatePublished - Sep 2021
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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