TY - JOUR
T1 - Outcomes of infants with hypoxic ischemic encephalopathy and persistent pulmonary hypertension of the newborn
T2 - results from three NICHD studies
AU - for the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) Neonatal Research Network
AU - Agarwal, Prashant
AU - Shankaran, Seetha
AU - Laptook, Abbot R.
AU - Chowdhury, Dhuly
AU - Lakshminrusimha, Satyan
AU - Bonifacio, Sonia Lomeli
AU - Natarajan, Girija
AU - Chawla, Sanjay
AU - Keszler, Martin
AU - Heyne, Roy J.
AU - Ambalavanan, Namasivayam
AU - Walsh, Michele C.
AU - Das, Abhik
AU - Van Meurs, Krisa P.
N1 - Funding Information:
Funding Supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (U10 HD21364, U10 HD21373, U10 HD21397, U10 HD21385, U10 HD27851, U10 HD27853, U10 HD27856, U10 HD27871, U10 HD27880, U10 HD27904, U10 HD34216, U10 HD36790, U10 HD40461, U10 HD40492, U10 HD40498, U10 HD40521, U10 20HD40689, U10 HD53089, U10 HD53109, U10 HD53124, U10 HD53119, U10 HD68244, U10 HD68263, U10 HD68270, U10 HD68278, U10 HD6828) and from the National Institutes of Health (M01 RR44, M01 RR30, M01 RR32, M01 RR39, M01 RR54, M01 RR70, M01 RR80, M01 RR633, M01 RR750, M01 RR2588, M01 RR7122, M01 RR8084, M01 RR16587, UL1 TR6, UL1 TR41, UL1 TR42, UL1 TR77, UL1 TR93, UL1 TR142, UL1 TR442, UL1 TR454, UL1 TR1117).
Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2021
Y1 - 2021
N2 - Objective: To determine the association of persistent pulmonary hypertension of the newborn (PPHN) with death or disability among infants with moderate or severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. Methods: We compared infants with and without PPHN enrolled in the hypothermia arm from three randomized controlled trials (RCTs): Induced Hypothermia trial, “usual care” arm of Optimizing Cooling trial, and Late Hypothermia trial. Primary outcome was death or disability at 18–22 months adjusted for severity of HIE, center, and RCT. Results: Among 280 infants, 67 (24%) were diagnosed with PPHN. Among infants with and without PPHN, death or disability was 47% vs. 29% (adjusted OR: 1.65, 0.86–3.14) and death was 26% vs. 12% (adjusted OR: 2.04, 0.92–4.53), respectively. Conclusions: PPHN in infants with moderate or severe HIE was not associated with a statistically significant increase in primary outcome. These results should be interpreted with caution given the limited sample size.
AB - Objective: To determine the association of persistent pulmonary hypertension of the newborn (PPHN) with death or disability among infants with moderate or severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia. Methods: We compared infants with and without PPHN enrolled in the hypothermia arm from three randomized controlled trials (RCTs): Induced Hypothermia trial, “usual care” arm of Optimizing Cooling trial, and Late Hypothermia trial. Primary outcome was death or disability at 18–22 months adjusted for severity of HIE, center, and RCT. Results: Among 280 infants, 67 (24%) were diagnosed with PPHN. Among infants with and without PPHN, death or disability was 47% vs. 29% (adjusted OR: 1.65, 0.86–3.14) and death was 26% vs. 12% (adjusted OR: 2.04, 0.92–4.53), respectively. Conclusions: PPHN in infants with moderate or severe HIE was not associated with a statistically significant increase in primary outcome. These results should be interpreted with caution given the limited sample size.
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U2 - 10.1038/s41372-020-00905-7
DO - 10.1038/s41372-020-00905-7
M3 - Article
C2 - 33402707
AN - SCOPUS:85098952589
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
ER -