Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure

Alex M. D'Angelo, Yoshifumi Naka, Joseph Sanchez, Yuji Kaku, Lucas Witer, Justin Fried, Amirali Masoumi, Maryjane A. Farr, Gabriel Sayer, Nir Uriel, Koji Takeda

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS). Methods: All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re-admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated. Results: Twenty-six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).

Original languageEnglish (US)
Pages (from-to)3381-3386
Number of pages6
JournalJournal of Cardiac Surgery
Volume35
Issue number12
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • heart transplantation
  • late allograft failure
  • mechanical circulatory support

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint

Dive into the research topics of 'Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure'. Together they form a unique fingerprint.

Cite this