Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure

Alex M. D'Angelo; Yoshifumi Naka; Joseph Sanchez; Yuji Kaku; Lucas Witer; Justin Fried; Amirali Masoumi; Maryjane A. Farr; Gabriel Sayer; Nir Uriel; Koji Takeda

doi:10.1111/jocs.15089

Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure

Alex M. D'Angelo, Yoshifumi Naka, Joseph Sanchez, Yuji Kaku, Lucas Witer, Justin Fried, Amirali Masoumi, Maryjane A. Farr, Gabriel Sayer, Nir Uriel, Koji Takeda

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Background: Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS). Methods: All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re-admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated. Results: Twenty-six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).

Original language	English (US)
Pages (from-to)	3381-3386
Number of pages	6
Journal	Journal of Cardiac Surgery
Volume	35
Issue number	12
DOIs	https://doi.org/10.1111/jocs.15089
State	Published - Dec 2020
Externally published	Yes

Keywords

heart transplantation
late allograft failure
mechanical circulatory support

ASJC Scopus subject areas

Surgery
Pulmonary and Respiratory Medicine
Cardiology and Cardiovascular Medicine

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10.1111/jocs.15089

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title = "Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure",

abstract = "Background: Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS). Methods: All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re-admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated. Results: Twenty-six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).",

keywords = "heart transplantation, late allograft failure, mechanical circulatory support",

author = "D'Angelo, {Alex M.} and Yoshifumi Naka and Joseph Sanchez and Yuji Kaku and Lucas Witer and Justin Fried and Amirali Masoumi and Farr, {Maryjane A.} and Gabriel Sayer and Nir Uriel and Koji Takeda",

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year = "2020",

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doi = "10.1111/jocs.15089",

language = "English (US)",

volume = "35",

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T1 - Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure

AU - D'Angelo, Alex M.

AU - Naka, Yoshifumi

AU - Sanchez, Joseph

AU - Kaku, Yuji

AU - Witer, Lucas

AU - Fried, Justin

AU - Masoumi, Amirali

AU - Farr, Maryjane A.

AU - Sayer, Gabriel

AU - Uriel, Nir

AU - Takeda, Koji

PY - 2020/12

Y1 - 2020/12

N2 - Background: Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS). Methods: All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re-admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated. Results: Twenty-six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).

AB - Background: Late graft failure (LGF) is an unresolved issue after orthotopic heart transplant (OHT). In this study, we report characteristics and outcomes of severe LGF requiring mechanical circulatory support (MCS). Methods: All patients undergoing OHT from 2000 to 2018 at our center were reviewed. Patients re-admitted to the hospital for late graft failure (>3 months after initial discharge) and developing cardiogenic shock requiring MCS were identified. Outcomes and mortality were evaluated. Results: Twenty-six patients were identified. Median age was 37.3 years (interquartile range: 28.2–47.6) and 69% were male. Median time from initial transplant to MCS was 2.9 years. Etiology of graft failure was rejection in 19 patients (73%), transplant coronary artery disease (tCAD) in 3 (12%), with mixed tCAD or rejection in 4 (15%).

KW - heart transplantation

KW - late allograft failure

KW - mechanical circulatory support

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JO - Journal of Cardiac Surgery

JF - Journal of Cardiac Surgery

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Outcomes of mechanical support for cardiogenic shock associated with late cardiac allograft failure

Abstract

Keywords

ASJC Scopus subject areas

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