Outcomes of treatment of gestational trophoblastic neoplasia in a primarily indigent urban population

Brittany A. Davidson, Christa I. Nagel, Debra L. Richardson, Siobhan M. Kehoe, David S. Miller, Jayanthi S. Lea

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

OBJECTIVE: To review outcomes of women with gestational trophoblastic neoplasia (GTN) who presented to an inner-city hospital system, given that the rigorous treatment and follow-up for GTN is often problematic for certain women of low socioeconomic status with limited resources and social support. STUDY DESIGN: A retrospective review was performed with IRB approval of patients diagnosed with GTN based on the revised WHO scoring system from 1999–2010 at our institution. SPSS Statistics software was used to perform univariate and multivariate analyses. RESULTS: Forty-nine patients were treated for GTN: 32 low-risk and 17 high-risk. Low-risk patients received an average of 5 cycles of initial single-agent chemotherapy. Six patients had persistent disease and were switched to a second single-agent regimen. One patient required multiagent chemotherapy for normalization of human chorionic gonadotropin levels. No patient had recurrence of disease. All high-risk patients were initially treated with multiagent chemotherapy, averaging 8 cycles. Two of the 17 patients persisted; 1 recurred. All 3 currently have no evidence of disease. No patient died of disease. CONCLUSION: Excellent treatment outcomes in patients with GTN may be achieved in disadvantaged populations when compliance to regimens is optimized.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalJournal of Reproductive Medicine
Volume60
Issue number3
StatePublished - Jun 1 2015

Fingerprint

Gestational Trophoblastic Disease
Urban Population
Poverty
Drug Therapy
Research Ethics Committees
Urban Hospitals
Vulnerable Populations
Chorionic Gonadotropin
Social Class
Social Support
Software
Multivariate Analysis

Keywords

  • Chemotherapy
  • Choriocarcinoma
  • Gestational trophoblastic neoplasia
  • Indigent
  • Outcomes

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Outcomes of treatment of gestational trophoblastic neoplasia in a primarily indigent urban population. / Davidson, Brittany A.; Nagel, Christa I.; Richardson, Debra L.; Kehoe, Siobhan M.; Miller, David S.; Lea, Jayanthi S.

In: Journal of Reproductive Medicine, Vol. 60, No. 3, 01.06.2015, p. 243-248.

Research output: Contribution to journalArticle

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