Outcomes of Treatment of Gestational Trophoblastic Neoplasia in a Primarily Indigent Urban Population

Brittany A. Davidson, Christa I. Nagel, Debra L. Richardson, Siobhan M. Kehoe, David S. Miller, Jayanthi S. Lea

Research output: Contribution to journalArticle

Abstract

RESULTS: Forty-nine patients were treated for GTN: 32 low-risk and 17 high-risk. Low-risk patients received an average of 5 cycles of initial single-agent chemotherapy. Six patients had persistent disease and were switched to a second single-agent regimen. One patient required multiagent chemotherapy for normalization of human chorionic gonadotropin levels. No patient had recurrence of disease. All high-risk patients were initially treated with multiagent chemotherapy, averaging 8 cycles. Two of the 17 patients persisted; 1 recurred. All 3 currently have no evidence of disease. No patient died of disease.

CONCLUSION: Excellent treatment outcomes in patients with GTN may be achieved in disadvantaged populations when compliance to regimens is optimized.

OBJECTIVE: To review outcomes of women with gestational trophoblastic neoplasia (GTN) who presented to an inner-city hospital system, given that the rigorous treatment and follow-up for GTN is often problematic for certain women of low socioeconomic status with limited resources and social support.

STUDY DESIGN: A retrospective review was performed with IRB approval of patients diagnosed with GTN based on the revised WHO scoring system from 1999-2010 at our institution. SPSS Statistics software was used to perform univariate and multivariate analyses.

Original languageEnglish (US)
Pages (from-to)243-248
Number of pages6
JournalJournal of Reproductive Medicine
Volume60
Issue number5-6
StatePublished - May 1 2015

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Gestational Trophoblastic Disease
Urban Population
Poverty
Drug Therapy
Research Ethics Committees
Urban Hospitals
Vulnerable Populations
Chorionic Gonadotropin
Social Class
Social Support
Software
Multivariate Analysis

ASJC Scopus subject areas

  • Medicine(all)

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Outcomes of Treatment of Gestational Trophoblastic Neoplasia in a Primarily Indigent Urban Population. / Davidson, Brittany A.; Nagel, Christa I.; Richardson, Debra L.; Kehoe, Siobhan M.; Miller, David S.; Lea, Jayanthi S.

In: Journal of Reproductive Medicine, Vol. 60, No. 5-6, 01.05.2015, p. 243-248.

Research output: Contribution to journalArticle

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