Outcomes with drug-coated balloons vs. drug-eluting stents in small-vessel coronary artery disease

Michael Megaly, Kevin Buda, Marwan Saad, Mariam Tawadros, Ayman Elbadawi, Mir Basir, J. Dawn Abbott, Stephane Rinfret, Khaldoon Alaswad, Emmanouil S. Brilakis

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The use of drug-coated balloons (DCBs) in small-vessel coronary artery disease (SVD) remains controversial. Methods: We performed a meta-analysis of all randomized controlled trials (RCTs) reporting the outcomes of DCB vs. DES in de-novo SVD. We included a total of 5 RCTs (1459 patients), with (DCB n = 734 and DES n = 725). Results: Over a median follow-up duration of 6 months, DCB was associated with smaller late lumen loss (LLL) compared with DES (mean difference −0.12 mm) (95% confidence intervals (CI) [−0.21, −0.03 mm], p = 0.01). Over a median follow-up of 12 months, both modalities had similar risk of major adverse cardiovascular events (MACE) (8.7% vs. 10.2%; odds ratio (OR): 0.94, 95% CI [0.49–1.79], p = 084), all-cause mortality (1.17% vs. 2.38%; OR: 0.53, 95% CI [0.16–1.75], p = 0.30), target lesion revascularization (TLR) (7.9% vs. 3.9%; OR: 1.26, 95% CI [0.51–3.14], p = 0.62), and target vessel revascularization (TVR) (8.2% vs. 7.8%; OR: 1.06, 95% CI [0.40–2.82], p = 0.91). DCBs were associated with lower risk of myocardial infarction (MI) compared with DES (1.55% vs. 3.31%; OR: 0.48, 95% CI [0.23–1.00], p = 0.05, I2 = 0%). Conclusion: PCI of SVD with DCBs is associated with smaller LLL, lower risk of MI, and similar risk of MACE, death, TLR, and TVR compared with DES over one year. DCB appears as an attractive alternative to DES in patients with de-novo SVD, but long-term clinical data are still needed.

Original languageEnglish (US)
JournalCardiovascular Revascularization Medicine
DOIs
StateAccepted/In press - 2021

Keywords

  • DCB
  • Drug-coated balloons
  • Drug-eluting balloons
  • Small-vessel disease coronary disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Outcomes with drug-coated balloons vs. drug-eluting stents in small-vessel coronary artery disease'. Together they form a unique fingerprint.

Cite this