Ovarian neoplasms in children

M. A. Skinner, M. G. Schlatter, S. A. Heifetz, J. L. Grosfeld, J. L. Ternberg, R. T. Soper

Research output: Contribution to journalArticle

89 Citations (Scopus)

Abstract

Objective: To review the clinical presentation, treatment, and outcome in a series of children with ovarian neoplasms. Design: A retrospective review of the medical records in a case series of 29 girls with ovarian neoplasms. The length of follow-up ranged from 6 months to 7 1/2 years and averaged 3.0 years in the girls with malignant tumors. Setting: The patients were treated at a large referral children's hospital. Patients: Twenty-nine girls with ovarian neoplasms were treated from 1976 to 1992. The average age of the patients was 10 years and ranged from 2 to 16 years. Main Outcome Measures: The principal outcomes examined were mortality and surgical morbidity. Results: The most common presenting symptoms for these ovarian tumors in pediatric patients included chronic abdominal pain, an abdominal mass, or distention. Three girls presented with precocious puberty or hirsutism. In 27 cases, the tumor was a primary ovarian lesion. In two patients, the ovarian mass was the presenting finding for a stage IV non-Hodgkin's lymphoma. Seventeen tumors were benign and 12 were malignant. Tumors originating from the germ-cell line predominated (n=17). Seven of the 10 ovarian malignant neoplasms were stage 1 at the time of diagnosis. All but one of the girls with malignant tumors received either adjunctive radiation therapy or multiple-agent chemotherapy. Two girls with sex cord/stromal cell tumors who presented with stage I disease ultimately developed widespread metastases. Both girls with large epithelial tumors survived. All of the girls with benign tumors and seven (70%) of 10 with malignant lesions survived. Conclusion: Ovarian tumors are unusual lesions in the pediatric population. Unlike in adults, such neoplasms generally originate from the germ-cell line. Whereas most ovarian tumors in girls are benign, some children have malignant tumors that are very aggressive and do not respond well to adjuvant therapy. In particular, malignant sex cord/stromal cell tumors, even when they present at an early stage, may behave unpredictably.

Original languageEnglish (US)
Pages (from-to)849-854
Number of pages6
JournalArchives of Surgery
Volume128
Issue number8
StatePublished - 1993

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Ovarian Neoplasms
Neoplasms
Sex Cord-Gonadal Stromal Tumors
Stromal Cells
Germ Cells
Pediatrics
Precocious Puberty
Hirsutism
Chronic Pain
Non-Hodgkin's Lymphoma
Abdominal Pain
Medical Records
Radiotherapy
Referral and Consultation
Outcome Assessment (Health Care)
Neoplasm Metastasis
Morbidity
Drug Therapy
Mortality

ASJC Scopus subject areas

  • Surgery

Cite this

Skinner, M. A., Schlatter, M. G., Heifetz, S. A., Grosfeld, J. L., Ternberg, J. L., & Soper, R. T. (1993). Ovarian neoplasms in children. Archives of Surgery, 128(8), 849-854.

Ovarian neoplasms in children. / Skinner, M. A.; Schlatter, M. G.; Heifetz, S. A.; Grosfeld, J. L.; Ternberg, J. L.; Soper, R. T.

In: Archives of Surgery, Vol. 128, No. 8, 1993, p. 849-854.

Research output: Contribution to journalArticle

Skinner, MA, Schlatter, MG, Heifetz, SA, Grosfeld, JL, Ternberg, JL & Soper, RT 1993, 'Ovarian neoplasms in children', Archives of Surgery, vol. 128, no. 8, pp. 849-854.
Skinner MA, Schlatter MG, Heifetz SA, Grosfeld JL, Ternberg JL, Soper RT. Ovarian neoplasms in children. Archives of Surgery. 1993;128(8):849-854.
Skinner, M. A. ; Schlatter, M. G. ; Heifetz, S. A. ; Grosfeld, J. L. ; Ternberg, J. L. ; Soper, R. T. / Ovarian neoplasms in children. In: Archives of Surgery. 1993 ; Vol. 128, No. 8. pp. 849-854.
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abstract = "Objective: To review the clinical presentation, treatment, and outcome in a series of children with ovarian neoplasms. Design: A retrospective review of the medical records in a case series of 29 girls with ovarian neoplasms. The length of follow-up ranged from 6 months to 7 1/2 years and averaged 3.0 years in the girls with malignant tumors. Setting: The patients were treated at a large referral children's hospital. Patients: Twenty-nine girls with ovarian neoplasms were treated from 1976 to 1992. The average age of the patients was 10 years and ranged from 2 to 16 years. Main Outcome Measures: The principal outcomes examined were mortality and surgical morbidity. Results: The most common presenting symptoms for these ovarian tumors in pediatric patients included chronic abdominal pain, an abdominal mass, or distention. Three girls presented with precocious puberty or hirsutism. In 27 cases, the tumor was a primary ovarian lesion. In two patients, the ovarian mass was the presenting finding for a stage IV non-Hodgkin's lymphoma. Seventeen tumors were benign and 12 were malignant. Tumors originating from the germ-cell line predominated (n=17). Seven of the 10 ovarian malignant neoplasms were stage 1 at the time of diagnosis. All but one of the girls with malignant tumors received either adjunctive radiation therapy or multiple-agent chemotherapy. Two girls with sex cord/stromal cell tumors who presented with stage I disease ultimately developed widespread metastases. Both girls with large epithelial tumors survived. All of the girls with benign tumors and seven (70{\%}) of 10 with malignant lesions survived. Conclusion: Ovarian tumors are unusual lesions in the pediatric population. Unlike in adults, such neoplasms generally originate from the germ-cell line. Whereas most ovarian tumors in girls are benign, some children have malignant tumors that are very aggressive and do not respond well to adjuvant therapy. In particular, malignant sex cord/stromal cell tumors, even when they present at an early stage, may behave unpredictably.",
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