Overcoming therapeutic inertia in patients with hypertension

Research output: Contribution to journalReview article

10 Scopus citations


Uncontrolled blood pressure (BP) remains a leading contributor to cardiovascular disease and mortality worldwide. Although current practice guidelines recommend treating patients with hypertension to defined BP goals, the approach is not widely implemented, and BP control in clinical practice is much worse than that attained in clinical trials. Recent and ongoing clinical trials are utilizing more aggressive approaches with combination therapy as initial treatment. This article discusses the problem of therapeutic or clinical inertia when attempting to control hypertension and highlights differences in BP control rates between clinical trials and real-world practice. Additionally, the rationale for an ongoing treat-to-goal study using a fixed-dose combination of amlodipin/olmesartan medoxomil in patients with hypertension not controlled on monotherapy is provided.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalPostgraduate medicine
Issue number1
StatePublished - Jan 1 2010



  • BP goal
  • Combination therapy
  • Hypertension

ASJC Scopus subject areas

  • Medicine(all)

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