Overdiagnosis

An Understudied Issue in Hepatocellular Carcinoma Surveillance

Nicole E. Rich, Neehar D. Parikh, Amit G. Singal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Overdiagnosis, the detection of clinically insignificant disease that would not otherwise impact the patient's lifespan, is a phenomenon that has been described in several solid tumors, such as prostate, breast, thyroid, and lung cancers. Population-based efforts to reduce hepatocellular carcinoma (HCC) mortality in cirrhosis patients by screening and early detection may result in the overdiagnosis of HCC. One of the harms of overdiagnosis is subsequent overtreatment, which can result in increased costs, as well as physical side effects, psychological harms, and poorer quality of life. In this review, the authors explore the potential for overdiagnosis in HCC.

Original languageEnglish (US)
Pages (from-to)296-304
Number of pages9
JournalSeminars in Liver Disease
Volume37
Issue number4
DOIs
StatePublished - Nov 1 2017

Fingerprint

Hepatocellular Carcinoma
Thyroid Neoplasms
Lung Neoplasms
Prostatic Neoplasms
Fibrosis
Quality of Life
Medical Overuse
Breast Neoplasms
Psychology
Costs and Cost Analysis
Mortality
Population
Neoplasms

Keywords

  • harms
  • HCC
  • overdiagnosis
  • overtreatment
  • screening
  • surveillance

ASJC Scopus subject areas

  • Hepatology

Cite this

Overdiagnosis : An Understudied Issue in Hepatocellular Carcinoma Surveillance. / Rich, Nicole E.; Parikh, Neehar D.; Singal, Amit G.

In: Seminars in Liver Disease, Vol. 37, No. 4, 01.11.2017, p. 296-304.

Research output: Contribution to journalArticle

Rich, Nicole E. ; Parikh, Neehar D. ; Singal, Amit G. / Overdiagnosis : An Understudied Issue in Hepatocellular Carcinoma Surveillance. In: Seminars in Liver Disease. 2017 ; Vol. 37, No. 4. pp. 296-304.
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