Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

A complementary DNA encoding the human low density lipoprotein (LDL) receptor under control of the mouse metallothionein-I promoter was injected into fertilized mouse eggs, and a strain of mice expressing high levels of LDL receptors was established. After administration of cadmium, these mice cleared intravenously injected 125I-labeled LDL from blood eight to ten times more rapidly than did normal mice. The plasma concentrations of apoproteins B-100 and E, the two ligands for the LDL receptor, declined by more than 90 percent after cadmium treatment, but the concentration of another apoprotein, A-I, was unaffected. Therefore, overexpression of an endocytotic receptor can dramatically lower the ambient concentration of its ligand in vivo.

Original languageEnglish (US)
Pages (from-to)1277-1281
Number of pages5
JournalScience
Volume239
Issue number4846
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • General

Fingerprint Dive into the research topics of 'Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice'. Together they form a unique fingerprint.

  • Cite this