TY - JOUR
T1 - Overexpression of SENP3 in oral squamous cell carcinoma and its association with differentiation
AU - Sun, Zujun
AU - Hu, Shuiqing
AU - Luo, Qingqiong
AU - Ye, Dongxia
AU - Hu, Dan
AU - Chen, Fuxiang
PY - 2013/5
Y1 - 2013/5
N2 - Small ubiquitin-like modifier (SUMO) modification is an important post-translational protein modification that can be reversed by SUMO-specific proteases (SENPs); however, the physiological function of SENPs remains largely unexplored, and little is known about the regulation of SENPs themselves. As one of the crucial members of the SUMO system, SENP3 is essential for rRNA processing and cell proliferation. In the present study, we analysed the expression of SENP3 in human oral squamous cell carcinoma (OSCC) and investigated the correlation between its expression and clinicopathological parameters in OSCC patients. The expression of SENP3 was higher in OSCC tissues than that in the normal mucosa adjacent to the tumor, and a modest increase in reactive oxygen species (ROS) regulated SENP3 stability and localization. ROS induced SENP3 redistribution from the nucleoli to the nucleoplasm. Taken together, these results indicated that the expression level of SENP3 may be associated with the differentiation of OSCC and that SENP3 may play an important role in the development of OSCC under oxidative stress.
AB - Small ubiquitin-like modifier (SUMO) modification is an important post-translational protein modification that can be reversed by SUMO-specific proteases (SENPs); however, the physiological function of SENPs remains largely unexplored, and little is known about the regulation of SENPs themselves. As one of the crucial members of the SUMO system, SENP3 is essential for rRNA processing and cell proliferation. In the present study, we analysed the expression of SENP3 in human oral squamous cell carcinoma (OSCC) and investigated the correlation between its expression and clinicopathological parameters in OSCC patients. The expression of SENP3 was higher in OSCC tissues than that in the normal mucosa adjacent to the tumor, and a modest increase in reactive oxygen species (ROS) regulated SENP3 stability and localization. ROS induced SENP3 redistribution from the nucleoli to the nucleoplasm. Taken together, these results indicated that the expression level of SENP3 may be associated with the differentiation of OSCC and that SENP3 may play an important role in the development of OSCC under oxidative stress.
KW - Oral squamous cell carcinoma
KW - Reactive oxygen species
KW - Small ubiquitin-like modifier
KW - Small ubiquitin-like modifier-specific proteases
UR - http://www.scopus.com/inward/record.url?scp=84876280247&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876280247&partnerID=8YFLogxK
U2 - 10.3892/or.2013.2318
DO - 10.3892/or.2013.2318
M3 - Article
C2 - 23467634
AN - SCOPUS:84876280247
SN - 1021-335X
VL - 29
SP - 1701
EP - 1706
JO - Oncology reports
JF - Oncology reports
IS - 5
ER -