Overlapping memory trace indispensable for linking, but not recalling, individual memories

Jun Yokose; Reiko Okubo-Suzuki; Masanori Nomoto; Noriaki Ohkawa; Hirofumi Nishizono; Akinobu Suzuki; Mina Matsuo; Shuhei Tsujimura; Yukari Takahashi; Masashi Nagase; Ayako M. Watabe; Masakiyo Sasahara; Fusao Kato; Kaoru Inokuchi

doi:10.1126/science.aal2690

Overlapping memory trace indispensable for linking, but not recalling, individual memories

Jun Yokose, Reiko Okubo-Suzuki, Masanori Nomoto, Noriaki Ohkawa, Hirofumi Nishizono, Akinobu Suzuki, Mina Matsuo, Shuhei Tsujimura, Yukari Takahashi, Masashi Nagase, Ayako M. Watabe, Masakiyo Sasahara, Fusao Kato, Kaoru Inokuchi

Research output: Contribution to journal › Article › peer-review

71 Scopus citations

Abstract

Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.

Original language	English (US)
Pages (from-to)	398-403
Number of pages	6
Journal	Science (New York, N.Y.)
Volume	355
Issue number	6323
DOIs	https://doi.org/10.1126/science.aal2690
State	Published - Jan 27 2017
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1126/science.aal2690

Cite this

Yokose, J., Okubo-Suzuki, R., Nomoto, M., Ohkawa, N., Nishizono, H., Suzuki, A., Matsuo, M., Tsujimura, S., Takahashi, Y., Nagase, M., Watabe, A. M., Sasahara, M., Kato, F., & Inokuchi, K. (2017). Overlapping memory trace indispensable for linking, but not recalling, individual memories. Science (New York, N.Y.), 355(6323), 398-403. https://doi.org/10.1126/science.aal2690

Yokose, J, Okubo-Suzuki, R, Nomoto, M, Ohkawa, N, Nishizono, H, Suzuki, A, Matsuo, M, Tsujimura, S, Takahashi, Y, Nagase, M, Watabe, AM, Sasahara, M, Kato, F & Inokuchi, K 2017, 'Overlapping memory trace indispensable for linking, but not recalling, individual memories', Science (New York, N.Y.), vol. 355, no. 6323, pp. 398-403. https://doi.org/10.1126/science.aal2690

@article{64c1430bad6d418ca3295decab3822bd,

title = "Overlapping memory trace indispensable for linking, but not recalling, individual memories",

abstract = "Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.",

author = "Jun Yokose and Reiko Okubo-Suzuki and Masanori Nomoto and Noriaki Ohkawa and Hirofumi Nishizono and Akinobu Suzuki and Mina Matsuo and Shuhei Tsujimura and Yukari Takahashi and Masashi Nagase and Watabe, {Ayako M.} and Masakiyo Sasahara and Fusao Kato and Kaoru Inokuchi",

note = "Publisher Copyright: Copyright {\textcopyright} 2017, American Association for the Advancement of Science.",

year = "2017",

month = jan,

day = "27",

doi = "10.1126/science.aal2690",

language = "English (US)",

volume = "355",

pages = "398--403",

journal = "Science (New York, N.Y.)",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "6323",

}

TY - JOUR

T1 - Overlapping memory trace indispensable for linking, but not recalling, individual memories

AU - Yokose, Jun

AU - Okubo-Suzuki, Reiko

AU - Nomoto, Masanori

AU - Ohkawa, Noriaki

AU - Nishizono, Hirofumi

AU - Suzuki, Akinobu

AU - Matsuo, Mina

AU - Tsujimura, Shuhei

AU - Takahashi, Yukari

AU - Nagase, Masashi

AU - Watabe, Ayako M.

AU - Sasahara, Masakiyo

AU - Kato, Fusao

AU - Inokuchi, Kaoru

PY - 2017/1/27

Y1 - 2017/1/27

N2 - Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.

AB - Memories are not stored in isolation from other memories but are integrated into associative networks. However, the mechanisms underlying memory association remain elusive. Using two amygdala-dependent behavioral paradigms-conditioned taste aversion (CTA) and auditory-cued fear conditioning (AFC)-in mice, we found that presenting the conditioned stimulus used for the CTA task triggered the conditioned response of the AFC task after natural coreactivation of the memories. This was accompanied through an increase in the overlapping neuronal ensemble in the basolateral amygdala. Silencing of the overlapping ensemble suppressed CTA retrieval-induced freezing. However, retrieval of the original CTA or AFC memory was not affected. A small population of coshared neurons thus mediates the link between memories. They are not necessary for recalling individual memories.

UR - http://www.scopus.com/inward/record.url?scp=85017156751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85017156751&partnerID=8YFLogxK

U2 - 10.1126/science.aal2690

DO - 10.1126/science.aal2690

M3 - Article

C2 - 28126819

AN - SCOPUS:85017156751

SN - 0036-8075

VL - 355

SP - 398

EP - 403

JO - Science (New York, N.Y.)

JF - Science (New York, N.Y.)

IS - 6323

ER -

Overlapping memory trace indispensable for linking, but not recalling, individual memories

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this