Oxaliplatin-induced immune mediated thrombocytopenia

Muhammad S. Beg, Rami S. Komrokji, Kashif Ahmed, Malek M. Safa

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Oxaliplatin is a third generation platinum compound used in patients with advanced colorectal carcinoma. Recently, the mechanism of a rare drug-induced immune thrombocytopenia in patients receiving oxaliplatin has been described. This complication is caused by oxaliplatin-dependent antibodies directed against platelet surface glycoproteins, and is unrelated to myelosuppression. In this report, we describe two patients who developed thrombocytopenia immediately soon after receiving oxaliplatin. Sensitization presumably had occurred after receiving oxaliplatin during preceding courses of multiagent chemotherapy that included oxaliplatin.

Original languageEnglish (US)
Pages (from-to)925-927
Number of pages3
JournalCancer Chemotherapy and Pharmacology
Volume62
Issue number5
DOIs
StatePublished - Oct 1 2008

Keywords

  • Immune
  • Oxaliplatin
  • Thrombocytopenia

ASJC Scopus subject areas

  • Oncology
  • Toxicology
  • Pharmacology
  • Cancer Research
  • Pharmacology (medical)

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