Oxidative Conversion of a Europium(II)-Based T1 Agent into a Europium(III)-Based paraCEST Agent that can be Detected in Vivo by Magnetic Resonance Imaging

Alexander M. Funk, Veronica ClavijoJordan, A. Dean Sherry, S. James Ratnakar, Zoltan Kovacs

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The EuII complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates reported to date. The reduced EuII form acts as an efficient water proton T1 relaxation reagent, while the EuIII form acts as a water-based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding EuIII complex yields a well-defined signal from the paraCEST agent. The time course of oxidation was studied in vitro and in vivo by T1-weighted and CEST imaging.

Original languageEnglish (US)
Pages (from-to)5024-5027
Number of pages4
JournalAngewandte Chemie - International Edition
Volume55
Issue number16
DOIs
StatePublished - Apr 11 2016

Keywords

  • T weighting
  • contrast agents
  • divalent lanthanides
  • europium
  • paraCEST

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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