Oxidative Conversion of a Europium(II)-Based T1 Agent to a Europium(III)-Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging

Alexander M. Funk, Veronica ClavijoJordan, A. Dean Sherry, S. James Ratnakar, Zoltan Kovacs

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The EuII complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates reported to date. The reduced EuII form acts as an efficient water proton T1 relaxation reagent, while the EuIII form acts as a water-based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding EuIII complex yields a well-defined signal from the paraCEST agent. The time course of oxidation was studied invitro and invivo by T1-weighted and CEST imaging.

Original languageEnglish (US)
JournalAngewandte Chemie - International Edition
DOIs
StateAccepted/In press - 2016

Fingerprint

Europium
Water
Oxidation
Protons
Ion exchange
Imaging techniques
Acids
Magnetic Resonance Imaging

Keywords

  • Contrast agents
  • Divalent lanthanides
  • Europium
  • ParaCEST
  • T weighting

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

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title = "Oxidative Conversion of a Europium(II)-Based T1 Agent to a Europium(III)-Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging",
abstract = "The EuII complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates reported to date. The reduced EuII form acts as an efficient water proton T1 relaxation reagent, while the EuIII form acts as a water-based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding EuIII complex yields a well-defined signal from the paraCEST agent. The time course of oxidation was studied invitro and invivo by T1-weighted and CEST imaging.",
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T1 - Oxidative Conversion of a Europium(II)-Based T1 Agent to a Europium(III)-Based paraCEST Agent that can be Detected In Vivo by Magnetic Resonance Imaging

AU - Funk, Alexander M.

AU - ClavijoJordan, Veronica

AU - Sherry, A. Dean

AU - Ratnakar, S. James

AU - Kovacs, Zoltan

PY - 2016

Y1 - 2016

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AB - The EuII complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates reported to date. The reduced EuII form acts as an efficient water proton T1 relaxation reagent, while the EuIII form acts as a water-based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding EuIII complex yields a well-defined signal from the paraCEST agent. The time course of oxidation was studied invitro and invivo by T1-weighted and CEST imaging.

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KW - Europium

KW - ParaCEST

KW - T weighting

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