Oxidative Conversion of a Europium(II)-Based T1 Agent into a Europium(III)-Based paraCEST Agent that can be Detected in Vivo by Magnetic Resonance Imaging

Alexander M. Funk; Veronica ClavijoJordan; A. Dean Sherry; S. James Ratnakar; Zoltan Kovacs

doi:10.1002/anie.201511649

Oxidative Conversion of a Europium(II)-Based T₁ Agent into a Europium(III)-Based paraCEST Agent that can be Detected in Vivo by Magnetic Resonance Imaging

Alexander M. Funk, Veronica ClavijoJordan, A. Dean Sherry, S. James Ratnakar, Zoltan Kovacs

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

The Eu^II complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most Eu^II chelates reported to date. The reduced Eu^II form acts as an efficient water proton T₁ relaxation reagent, while the Eu^III form acts as a water-based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding Eu^III complex yields a well-defined signal from the paraCEST agent. The time course of oxidation was studied in vitro and in vivo by T₁-weighted and CEST imaging.

Original language	English (US)
Pages (from-to)	5024-5027
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	55
Issue number	16
DOIs	https://doi.org/10.1002/anie.201511649
State	Published - Apr 11 2016

Keywords

T weighting
contrast agents
divalent lanthanides
europium
paraCEST

ASJC Scopus subject areas

Catalysis
General Chemistry

Access to Document

10.1002/anie.201511649

Cite this

Oxidative Conversion of a Europium(II)-Based T₁ Agent into a Europium(III)-Based paraCEST Agent that can be Detected in Vivo by Magnetic Resonance Imaging. / Funk, Alexander M.; ClavijoJordan, Veronica; Sherry, A. Dean et al.
In: Angewandte Chemie - International Edition, Vol. 55, No. 16, 11.04.2016, p. 5024-5027.

Research output: Contribution to journal › Article › peer-review

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abstract = "The EuII complex of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) tetra(glycinate) has a higher reduction potential than most EuII chelates reported to date. The reduced EuII form acts as an efficient water proton T1 relaxation reagent, while the EuIII form acts as a water-based chemical exchange saturation transfer (CEST) agent. The complex has extremely fast water exchange rate. Oxidation to the corresponding EuIII complex yields a well-defined signal from the paraCEST agent. The time course of oxidation was studied in vitro and in vivo by T1-weighted and CEST imaging.",

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