TY - JOUR
T1 - Oxidative stress-mediated HMGB1 biology
AU - Yu, Yan
AU - Tang, Daolin
AU - Kang, Rui
N1 - Publisher Copyright:
© 2015 Yu, Tang and Kang.
PY - 2015
Y1 - 2015
N2 - High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundantprotein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e.g., necrosis, apoptosis, autophagic cell death, pyroptosis, and NETosis). Thus, targeting HMGB1 with antioxidant compounds may be an attractive therapeutic strategy for inflammation-associated diseases such as sepsis, ischemia and reperfusion injury, arthritis, diabetes, and cancer.
AB - High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundantprotein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e.g., necrosis, apoptosis, autophagic cell death, pyroptosis, and NETosis). Thus, targeting HMGB1 with antioxidant compounds may be an attractive therapeutic strategy for inflammation-associated diseases such as sepsis, ischemia and reperfusion injury, arthritis, diabetes, and cancer.
KW - Apoptosis
KW - Autophagy
KW - HMGB1
KW - Inflammation
KW - NETosis
KW - Necrosis
KW - Pyroptosis
KW - ROS
UR - http://www.scopus.com/inward/record.url?scp=84926476595&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84926476595&partnerID=8YFLogxK
U2 - 10.3389/fphys.2015.00093
DO - 10.3389/fphys.2015.00093
M3 - Article
C2 - 25904867
AN - SCOPUS:84926476595
SN - 1664-042X
VL - 6
JO - Frontiers in Physiology
JF - Frontiers in Physiology
IS - MAR
M1 - 93
ER -