TY - JOUR
T1 - Oxygen in stem cell biology
T2 - A critical component of the stem cell niche
AU - Mohyeldin, Ahmed
AU - Garzón-Muvdi, Tomás
AU - Quiñones-Hinojosa, Alfredo
N1 - Funding Information:
We would like to thank three anonymous reviewers for comments on the manuscript, and we apologize to those colleagues whose work we could not reference directly due to space constraints. In addition, we would like to thank A. Yaktieen and A. Ibrahim for their graphic design technical input and A. Verma for his conceptual input for the cancer stem cell niche figure and for inspiring the concept behind the review. A.M. would like to thank S. Ashrafi and G. Vela for brainstorming and discussions on the stem cell niche. This work was supported by funds from the National Institutes of Health (NIH, KO8 Grant, no. K08NS055851) and the Howard Hughes Medical Institute. A.M. and T.G.M. were supported by the Maryland Stem Cell Postdoctoral Research Fellowship.
PY - 2010/8/6
Y1 - 2010/8/6
N2 - The defining hallmark of stem cells is their ability to self-renew and maintain multipotency. This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and also influence proliferation and cell-fate commitment. Recent evidence has identified a broader spectrum of stem cells influenced by hypoxia that includes cancer stem cells and induced pluripotent stem cells. These findings have important implications on our understanding of development, disease, and tissue-engineering practices and furthermore elucidate an added dimension of stem cell control within the niche.
AB - The defining hallmark of stem cells is their ability to self-renew and maintain multipotency. This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and also influence proliferation and cell-fate commitment. Recent evidence has identified a broader spectrum of stem cells influenced by hypoxia that includes cancer stem cells and induced pluripotent stem cells. These findings have important implications on our understanding of development, disease, and tissue-engineering practices and furthermore elucidate an added dimension of stem cell control within the niche.
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U2 - 10.1016/j.stem.2010.07.007
DO - 10.1016/j.stem.2010.07.007
M3 - Review article
C2 - 20682444
AN - SCOPUS:77956224494
SN - 1934-5909
VL - 7
SP - 150
EP - 161
JO - Cell Stem Cell
JF - Cell Stem Cell
IS - 2
ER -