Oxygen-sensitive 19F NMR imaging of the vascular system in vivo

Joel E. Fishman; Peter M. Joseph; Thomas F. Floyd; Biswanath Mukherji; Henry A. Sloviter

doi:10.1016/0730-725X(87)90005-1

Oxygen-sensitive ¹⁹F NMR imaging of the vascular system in vivo

Joel E. Fishman, Peter M. Joseph, Thomas F. Floyd, Biswanath Mukherji, Henry A. Sloviter

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

The fluorine nuclear magnetic resonance spin-lattice relaxation rate ( 1 T₁) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by ¹⁹F MR imaging. We obtained oxygen-sensitive ¹⁹F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O₂-breathing. T₁ relaxation times were derived from MR images using a partial saturation pulse sequence. The T₁ times were compared with a phantom calibration curve to calculate average blood pO₂ values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O₂ instead of air.

Original language	English (US)
Pages (from-to)	279-285
Number of pages	7
Journal	Magnetic Resonance Imaging
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/0730-725X(87)90005-1
State	Published - 1987

Keywords

Blood oxygenation
Cardiovascular MR imaging
Fluorine NMR
Fluorocarbons
T measurement

ASJC Scopus subject areas

Biophysics
Biomedical Engineering
Radiology Nuclear Medicine and imaging

Access to Document

10.1016/0730-725X(87)90005-1

Cite this

@article{c2e28c0992574efab0150ff163cc98bf,

title = "Oxygen-sensitive 19F NMR imaging of the vascular system in vivo",

abstract = "The fluorine nuclear magnetic resonance spin-lattice relaxation rate ( 1 T1) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by 19F MR imaging. We obtained oxygen-sensitive 19F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O2-breathing. T1 relaxation times were derived from MR images using a partial saturation pulse sequence. The T1 times were compared with a phantom calibration curve to calculate average blood pO2 values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O2 instead of air.",

keywords = "Blood oxygenation, Cardiovascular MR imaging, Fluorine NMR, Fluorocarbons, T measurement",

author = "Fishman, {Joel E.} and Joseph, {Peter M.} and Floyd, {Thomas F.} and Biswanath Mukherji and Sloviter, {Henry A.}",

note = "Funding Information: was supported by grant l-ROl-CA40451 from the U.S. National Institutes of Health. Joel Fishman is supported by N.I.H. Grant No. 5-T32-GM07170 (Medical Scientist Training Program).",

year = "1987",

doi = "10.1016/0730-725X(87)90005-1",

language = "English (US)",

volume = "5",

pages = "279--285",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier Inc.",

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T1 - Oxygen-sensitive 19F NMR imaging of the vascular system in vivo

AU - Fishman, Joel E.

AU - Joseph, Peter M.

AU - Floyd, Thomas F.

AU - Mukherji, Biswanath

AU - Sloviter, Henry A.

N1 - Funding Information: was supported by grant l-ROl-CA40451 from the U.S. National Institutes of Health. Joel Fishman is supported by N.I.H. Grant No. 5-T32-GM07170 (Medical Scientist Training Program).

PY - 1987

Y1 - 1987

N2 - The fluorine nuclear magnetic resonance spin-lattice relaxation rate ( 1 T1) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by 19F MR imaging. We obtained oxygen-sensitive 19F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O2-breathing. T1 relaxation times were derived from MR images using a partial saturation pulse sequence. The T1 times were compared with a phantom calibration curve to calculate average blood pO2 values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O2 instead of air.

AB - The fluorine nuclear magnetic resonance spin-lattice relaxation rate ( 1 T1) of the perfluorochemical blood substitute perfluorotripropylamine (FTPA) is very sensitive to oxygen tension. This presents the possibility of measuring blood oxygen tension by 19F MR imaging. We obtained oxygen-sensitive 19F NMR images of the circulatory system of rats infused with emulsified FTPA. Blood oxygenation was assessed under conditions of both air- and 100% O2-breathing. T1 relaxation times were derived from MR images using a partial saturation pulse sequence. The T1 times were compared with a phantom calibration curve to calculate average blood pO2 values in the lung, liver, and spleen. The results showed marked, organ-specific increases in blood oxygen tension when the rat breathed 100% O2 instead of air.

KW - Blood oxygenation

KW - Cardiovascular MR imaging

KW - Fluorine NMR

KW - Fluorocarbons

KW - T measurement

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