Oxygen tension mapping with F‐19 echo‐planar MR imaging of sequestered perfluorocarbon

B. R. Barker, Ralph P Mason, N. Bansal, Ronald M Peshock

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

The authors used fluorine‐19 inversion‐recovery (IR) echo‐planar imaging (EPI) to map oxygen tension on the basis of the spin‐lattice relaxation rate (R1) of sequestered perfluorocarbon. R1 measured with IR‐EPI varied as a linear function of oxygen tension and temperature, and the relationship agreed well with earlier spectroscopic findings. Oxygen tension maps of a mouse that had received a dose of perflubron emulsion were acquired before, during, and after the mouse breathed pure oxygen. Results showed low liver oxygen tension during air breathing, which increased during breathing of pure oxygen, with distinct regional heterogeneity, to 8–17%atm (60–130 torr [8.0–17.3 kPa]).

Original languageEnglish (US)
Pages (from-to)595-602
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Volume4
Issue number4
DOIs
StatePublished - Jan 1 1994

Keywords

  • Fluorine studies
  • Liver, MR, 761.121416
  • Oxygen
  • Perflubron Relaxometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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