Oxygenation in a human tumor xenograft: Manipulation through respiratory challenge and antibody-directed infarction

Ralph P. Mason, Anca Constantinescu, Sophia Ran, Philip E. Thorpe

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

We recently demonstrated the use of 19F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.

Original languageEnglish (US)
Pages (from-to)197-204
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume530
Publication statusPublished - 2003

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Keywords

  • Antibody targeting
  • Hexafluorobenzene
  • Magnetic resonance imaging
  • Oxygen
  • Tissue factor
  • Tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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