Oxygenation in a human tumor xenograft: Manipulation through respiratory challenge and antibody-directed infarction

Ralph P. Mason; Anca Constantinescu; Sophia Ran; Philip E. Thorpe

doi:10.1007/978-1-4615-0075-9_19

Oxygenation in a human tumor xenograft: Manipulation through respiratory challenge and antibody-directed infarction

Ralph P. Mason, Anca Constantinescu, Sophia Ran, Philip E. Thorpe

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

We recently demonstrated the use of ¹⁹F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.

Original language	English (US)
Pages (from-to)	197-204
Number of pages	8
Journal	Advances in experimental medicine and biology
Volume	530
DOIs	https://doi.org/10.1007/978-1-4615-0075-9_19
State	Published - 2003

Keywords

Antibody targeting
Hexafluorobenzene
Magnetic resonance imaging
Oxygen
Tissue factor
Tumor

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1007/978-1-4615-0075-9_19

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abstract = "We recently demonstrated the use of 19F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.",

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AU - Constantinescu, Anca

AU - Ran, Sophia

AU - Thorpe, Philip E.

PY - 2003

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AB - We recently demonstrated the use of 19F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.

KW - Antibody targeting

KW - Hexafluorobenzene

KW - Magnetic resonance imaging

KW - Oxygen

KW - Tissue factor

KW - Tumor

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JO - Advances in Experimental Medicine and Biology

JF - Advances in Experimental Medicine and Biology

ER -

Oxygenation in a human tumor xenograft: Manipulation through respiratory challenge and antibody-directed infarction

Abstract

Keywords

ASJC Scopus subject areas

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