We recently demonstrated the use of 19F NMR relaxometry of hexafluorobenzene to monitor regional tumor oxygen tension dynamics in rats. We have now extended the application to human tumors implanted in immunocompromised (SCID) mice. This has allowed us both to investigate dynamic response to respiratory challenge (carbogen) and to probe the mechanisms of a new anti-vascular therapy designed to produce tumor-specific infarction.
- Antibody targeting
- Magnetic resonance imaging
- Tissue factor
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)