Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical evaluation of tumor hypoxia. This study examined the potential use of blood oxygenation level-dependent (BOLD) contrast MRI as a noninvasive technique to assess tumor vascular oxygenation at 3T. Following Institutional Review Board-approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic T2*-weighted MRI was performed in the transaxial plane using a multi-shot echo planar imaging sequence whilst patients breathed room air followed by oxygen (15 dm3/min). Later, a multi-echo gradient echo examination was added to provide quantitative R2* measurements. The baseline T2*-weighted signal intensity was quite stable, but increased to various extents in tumors on initiation of oxygen breathing. The signal in normal uterus increased significantly, whereas that in the iliacus muscle did not change. R2* responded significantly in healthy uterus, cervix and eight cervical tumors. This preliminary study demonstrates that BOLD MRI of cervical cancer at 3T is feasible. However, more patients must be evaluated and followed clinically before any prognostic value can be determined.

Original languageEnglish (US)
Pages (from-to)1321-1330
Number of pages10
JournalNMR in Biomedicine
Volume25
Issue number12
DOIs
StatePublished - Dec 2012

Fingerprint

Oxygenation
Uterine Cervical Neoplasms
Magnetic resonance imaging
Tumors
Blood
Oxygen
Echo-Planar Imaging
Health Insurance Portability and Accountability Act
Patients' Rooms
Neoplasms
Gynecology
Research Ethics Committees
Obstetrics
Health insurance
Informed Consent
Cervix Uteri
Uterus
Blood Vessels
Healthy Volunteers
Respiration

Keywords

  • BOLD
  • Cervical cancer
  • Hypoxia
  • MRI
  • Oxygen

ASJC Scopus subject areas

  • Spectroscopy
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

@article{e061b4b2a07a4c989d97f64112213c71,
title = "Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T",
abstract = "Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical evaluation of tumor hypoxia. This study examined the potential use of blood oxygenation level-dependent (BOLD) contrast MRI as a noninvasive technique to assess tumor vascular oxygenation at 3T. Following Institutional Review Board-approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic T2*-weighted MRI was performed in the transaxial plane using a multi-shot echo planar imaging sequence whilst patients breathed room air followed by oxygen (15 dm3/min). Later, a multi-echo gradient echo examination was added to provide quantitative R2* measurements. The baseline T2*-weighted signal intensity was quite stable, but increased to various extents in tumors on initiation of oxygen breathing. The signal in normal uterus increased significantly, whereas that in the iliacus muscle did not change. R2* responded significantly in healthy uterus, cervix and eight cervical tumors. This preliminary study demonstrates that BOLD MRI of cervical cancer at 3T is feasible. However, more patients must be evaluated and followed clinically before any prognostic value can be determined.",
keywords = "BOLD, Cervical cancer, Hypoxia, MRI, Oxygen",
author = "Hallac, {Rami R.} and Yao Ding and Qing Yuan and Mccoll, {Roderick W.} and Jayanthi Lea and Sims, {Robert D.} and Weatherall, {Paul T.} and Mason, {Ralph P.}",
year = "2012",
month = "12",
doi = "10.1002/nbm.2804",
language = "English (US)",
volume = "25",
pages = "1321--1330",
journal = "NMR in Biomedicine",
issn = "0952-3480",
publisher = "John Wiley and Sons Ltd",
number = "12",

}

TY - JOUR

T1 - Oxygenation in cervical cancer and normal uterine cervix assessed using blood oxygenation level-dependent (BOLD) MRI at 3T

AU - Hallac, Rami R.

AU - Ding, Yao

AU - Yuan, Qing

AU - Mccoll, Roderick W.

AU - Lea, Jayanthi

AU - Sims, Robert D.

AU - Weatherall, Paul T.

AU - Mason, Ralph P.

PY - 2012/12

Y1 - 2012/12

N2 - Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical evaluation of tumor hypoxia. This study examined the potential use of blood oxygenation level-dependent (BOLD) contrast MRI as a noninvasive technique to assess tumor vascular oxygenation at 3T. Following Institutional Review Board-approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic T2*-weighted MRI was performed in the transaxial plane using a multi-shot echo planar imaging sequence whilst patients breathed room air followed by oxygen (15 dm3/min). Later, a multi-echo gradient echo examination was added to provide quantitative R2* measurements. The baseline T2*-weighted signal intensity was quite stable, but increased to various extents in tumors on initiation of oxygen breathing. The signal in normal uterus increased significantly, whereas that in the iliacus muscle did not change. R2* responded significantly in healthy uterus, cervix and eight cervical tumors. This preliminary study demonstrates that BOLD MRI of cervical cancer at 3T is feasible. However, more patients must be evaluated and followed clinically before any prognostic value can be determined.

AB - Hypoxia is reported to be a biomarker for poor prognosis in cervical cancer. However, a practical noninvasive method is needed for the routine clinical evaluation of tumor hypoxia. This study examined the potential use of blood oxygenation level-dependent (BOLD) contrast MRI as a noninvasive technique to assess tumor vascular oxygenation at 3T. Following Institutional Review Board-approved informed consent and in compliance with the Health Insurance Portability and Accountability Act, successful results were achieved in nine patients with locally advanced cervical cancer [International Federation of Gynecology and Obstetrics (FIGO) stage IIA to IVA] and three normal volunteers. In the first four patients, dynamic T2*-weighted MRI was performed in the transaxial plane using a multi-shot echo planar imaging sequence whilst patients breathed room air followed by oxygen (15 dm3/min). Later, a multi-echo gradient echo examination was added to provide quantitative R2* measurements. The baseline T2*-weighted signal intensity was quite stable, but increased to various extents in tumors on initiation of oxygen breathing. The signal in normal uterus increased significantly, whereas that in the iliacus muscle did not change. R2* responded significantly in healthy uterus, cervix and eight cervical tumors. This preliminary study demonstrates that BOLD MRI of cervical cancer at 3T is feasible. However, more patients must be evaluated and followed clinically before any prognostic value can be determined.

KW - BOLD

KW - Cervical cancer

KW - Hypoxia

KW - MRI

KW - Oxygen

UR - http://www.scopus.com/inward/record.url?scp=84868131570&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84868131570&partnerID=8YFLogxK

U2 - 10.1002/nbm.2804

DO - 10.1002/nbm.2804

M3 - Article

C2 - 22619091

AN - SCOPUS:84868131570

VL - 25

SP - 1321

EP - 1330

JO - NMR in Biomedicine

JF - NMR in Biomedicine

SN - 0952-3480

IS - 12

ER -