Oxytocin receptor polymorphism decreases midline neural activations to social stimuli in anorexia nervosa

Margarita Sala, Kihwan Han, Summer Acevedo, Daniel Krawczyk, Carrie McAdams

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Oxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network.

Original languageEnglish (US)
Article number2183
JournalFrontiers in Psychology
Volume9
Issue numberNOV
DOIs
StatePublished - Nov 13 2018

Fingerprint

Oxytocin Receptors
Anorexia Nervosa
Single Nucleotide Polymorphism
Social Behavior
Gyrus Cinguli
Social Perception
Occipital Lobe
Biological Models
Brain
Feeding Behavior
Oxytocin
Prefrontal Cortex
Neurotransmitter Agents
Psychiatry
Weight Loss
Eating
Alleles
Magnetic Resonance Imaging
Genes

Keywords

  • Anxiety
  • Depression
  • Eating disorders
  • Endophenotypes
  • FMRI
  • Neuroimaging
  • Self-perception
  • Social cognition

ASJC Scopus subject areas

  • Psychology(all)

Cite this

Oxytocin receptor polymorphism decreases midline neural activations to social stimuli in anorexia nervosa. / Sala, Margarita; Han, Kihwan; Acevedo, Summer; Krawczyk, Daniel; McAdams, Carrie.

In: Frontiers in Psychology, Vol. 9, No. NOV, 2183, 13.11.2018.

Research output: Contribution to journalArticle

@article{773e28e7b0924de4a0982bb0d18299c7,
title = "Oxytocin receptor polymorphism decreases midline neural activations to social stimuli in anorexia nervosa",
abstract = "Oxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network.",
keywords = "Anxiety, Depression, Eating disorders, Endophenotypes, FMRI, Neuroimaging, Self-perception, Social cognition",
author = "Margarita Sala and Kihwan Han and Summer Acevedo and Daniel Krawczyk and Carrie McAdams",
year = "2018",
month = "11",
day = "13",
doi = "10.3389/fpsyg.2018.02183",
language = "English (US)",
volume = "9",
journal = "Frontiers in Psychology",
issn = "1664-1078",
publisher = "Frontiers Research Foundation",
number = "NOV",

}

TY - JOUR

T1 - Oxytocin receptor polymorphism decreases midline neural activations to social stimuli in anorexia nervosa

AU - Sala, Margarita

AU - Han, Kihwan

AU - Acevedo, Summer

AU - Krawczyk, Daniel

AU - McAdams, Carrie

PY - 2018/11/13

Y1 - 2018/11/13

N2 - Oxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network.

AB - Oxytocin is a neurotransmitter related to both feeding and social behavior; anorexia nervosa is a psychiatric illness defined by reduced food intake, weight loss, and problems in social perceptions. Oxytocin receptor single nucleotide polymorphisms rs2254298 or rs53576 and neural responses to social stimuli were evaluated in adult women with or recovered from anorexia nervosa using functional magnetic resonance imaging. Carriers of the A allele for OXTR rs2254298 (2 AA and 10 AG) showed significantly reduced activation of portions of the posterior cingulate cortex and medial prefrontal cortex for social stimuli as well as greater negative connectivity between the posterior cingulate and the occipital lobe relative to the GG subjects for rs2254298. Differences in the other OXTR SNP, rs53576, did not result in detectable neural differences in either whole brain or region of interest analyses. Development of a mechanistic, biological model of how social behavior is impacted by mental illness requires linking genes to functional brain activations in disease. This pilot study suggests that in anorexia nervosa, differences related to OXTR SNP rs2254298 may alter neural responses to social stimuli and disrupt the engagement and disengagement of the default mode network.

KW - Anxiety

KW - Depression

KW - Eating disorders

KW - Endophenotypes

KW - FMRI

KW - Neuroimaging

KW - Self-perception

KW - Social cognition

UR - http://www.scopus.com/inward/record.url?scp=85056375864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056375864&partnerID=8YFLogxK

U2 - 10.3389/fpsyg.2018.02183

DO - 10.3389/fpsyg.2018.02183

M3 - Article

C2 - 30542304

AN - SCOPUS:85056375864

VL - 9

JO - Frontiers in Psychology

JF - Frontiers in Psychology

SN - 1664-1078

IS - NOV

M1 - 2183

ER -