P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair

Andrew N. Bankston, Wenqi Li, Hui Zhang, Li Ku, Guanglu Liu, Filomena Papa, Lixia Zhao, James A. Bibb, Franca Cambi, Seema K. Tiwari-Woodruff, Yue Feng

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.

Original languageEnglish (US)
Pages (from-to)18047-18057
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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