P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair

Andrew N. Bankston, Wenqi Li, Hui Zhang, Li Ku, Guanglu Liu, Filomena Papa, Lixia Zhao, James A. Bibb, Franca Cambi, Seema K. Tiwari-Woodruff, Yue Feng

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Cyclin-dependent kinase 5 (Cdk5) is crucial for brain development. Results: In contrast to neurons that utilize p35 as the primary Cdk5 activator, oligodendroglia employ p39-dependent Cdk5 activation to advance differentiation and myelin repair. Conclusion: p39 is the primary Cdk5 activator in oligodendroglia, essential for oligodendroglia development. Significance: Our study revealed distinct mechanisms controlling Cdk5 activity in neurons and oligodendroglia.

Original languageEnglish (US)
Pages (from-to)18047-18057
Number of pages11
JournalJournal of Biological Chemistry
Volume288
Issue number25
DOIs
StatePublished - Jun 21 2013

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Cyclin-Dependent Kinase 5
Oligodendroglia
Myelin Sheath
Repair
Neurons
Brain
Chemical activation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

Cite this

P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair. / Bankston, Andrew N.; Li, Wenqi; Zhang, Hui; Ku, Li; Liu, Guanglu; Papa, Filomena; Zhao, Lixia; Bibb, James A.; Cambi, Franca; Tiwari-Woodruff, Seema K.; Feng, Yue.

In: Journal of Biological Chemistry, Vol. 288, No. 25, 21.06.2013, p. 18047-18057.

Research output: Contribution to journalArticle

Bankston, Andrew N. ; Li, Wenqi ; Zhang, Hui ; Ku, Li ; Liu, Guanglu ; Papa, Filomena ; Zhao, Lixia ; Bibb, James A. ; Cambi, Franca ; Tiwari-Woodruff, Seema K. ; Feng, Yue. / P39, the primary activator for cyclin-dependent kinase 5 (CDK5) in oligodendroglia, is essential for oligodendroglia differentiation and myelin repair. In: Journal of Biological Chemistry. 2013 ; Vol. 288, No. 25. pp. 18047-18057.
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AU - Zhang, Hui

AU - Ku, Li

AU - Liu, Guanglu

AU - Papa, Filomena

AU - Zhao, Lixia

AU - Bibb, James A.

AU - Cambi, Franca

AU - Tiwari-Woodruff, Seema K.

AU - Feng, Yue

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