p53 in the game of transposons

Annika Wylie, Amanda E. Jones, John M. Abrams

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Throughout the animal kingdom, p53 genes function to restrain mobile elements and recent observations indicate that transposons become derepressed in human cancers. Together, these emerging lines of evidence suggest that cancers driven by p53 mutations could represent “transpospoathies,” i.e. disease states linked to eruptions of mobile elements. The transposopathy hypothesis predicts that p53 acts through conserved mechanisms to contain transposon movement, and in this way, prevents tumor formation. How transposon eruptions provoke neoplasias is not well understood but, from a broader perspective, this hypothesis also provides an attractive framework to explore unrestrained mobile elements as inciters of late-onset idiopathic disease. Also see the video abstract here.

Original languageEnglish (US)
Pages (from-to)1111-1116
Number of pages6
JournalBioEssays
Volume38
Issue number11
DOIs
Publication statusPublished - Nov 1 2016

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Keywords

  • Drosophila
  • human cancers
  • mobile elements
  • mouse cancer models
  • p53
  • piRNAs
  • retrotransposons
  • zebrafish

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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