p53: The Janus of autophagy?

Beth Levine, John Abrams

Research output: Contribution to journalArticlepeer-review

171 Scopus citations

Abstract

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

Original languageEnglish (US)
Pages (from-to)637-639
Number of pages3
JournalNature cell biology
Volume10
Issue number6
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Cell Biology

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