p53: The Janus of autophagy?

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Abstract

The autophagy pathway functions in adaptation to nutrient stress and tumour suppression. The p53 tumour suppressor, previously thought to positively regulate autophagy, may also inhibit it. This dual interplay between p53 and autophagy regulation is enigmatic, but may underlie key aspects of metabolism and cancer biology.

Original languageEnglish (US)
Pages (from-to)637-639
Number of pages3
JournalNature Cell Biology
Volume10
Issue number6
DOIs
Publication statusPublished - Jun 2008

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ASJC Scopus subject areas

  • Cell Biology

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