p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1

Kyra Nicole Laubach; Wensheng Yan; Xiangmudong Kong; Wenqiang Sun; Mingyi Chen; Jin Zhang; Xinbin Chen

doi:10.1073/pnas.2123202119

p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1

Kyra Nicole Laubach, Wensheng Yan, Xiangmudong Kong, Wenqiang Sun, Mingyi Chen, Jin Zhang, Xinbin Chen

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.

Original language	English (US)
Pages (from-to)	e2123202119
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	119
Issue number	22
DOIs	https://doi.org/10.1073/pnas.2123202119
State	Published - May 31 2022
Externally published	Yes

Keywords

Notch1 pathway
p53 family
p73
p73 C-terminal isoforms
tumor suppressor

ASJC Scopus subject areas

General

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10.1073/pnas.2123202119

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title = "p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1",

abstract = "Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.",

keywords = "Notch1 pathway, p53 family, p73, p73 C-terminal isoforms, tumor suppressor",

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T1 - p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1

AU - Laubach, Kyra Nicole

AU - Yan, Wensheng

AU - Kong, Xiangmudong

AU - Sun, Wenqiang

AU - Chen, Mingyi

AU - Zhang, Jin

AU - Chen, Xinbin

PY - 2022/5/31

Y1 - 2022/5/31

N2 - Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.

AB - Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.

KW - Notch1 pathway

KW - p53 family

KW - p73

KW - p73 C-terminal isoforms

KW - tumor suppressor

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JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 22

ER -

p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1

Abstract

Keywords

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