Abstract
Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.
Original language | English (US) |
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Pages (from-to) | e2123202119 |
Journal | Proceedings of the National Academy of Sciences of the United States of America |
Volume | 119 |
Issue number | 22 |
DOIs | |
State | Published - May 31 2022 |
Externally published | Yes |
Keywords
- Notch1 pathway
- p53 family
- p73
- p73 C-terminal isoforms
- tumor suppressor
ASJC Scopus subject areas
- General