p73α1, a p73 C-terminal isoform, regulates tumor suppression and the inflammatory response via Notch1

Kyra Nicole Laubach, Wensheng Yan, Xiangmudong Kong, Wenqiang Sun, Mingyi Chen, Jin Zhang, Xinbin Chen

Research output: Contribution to journalArticlepeer-review

Abstract

Significance p73 is expressed as multiple C-terminal isoforms, but their expression and activity are largely unknown. Here, we identified p73α1 as a p73 C-terminal isoform that results from exon 12 (E12) exclusion. We showed that E12 deficiency in mice leads to systemic inflammation but not spontaneous tumors. We also showed that Notch1 is regulated by p73α1 and plays a critical role in p73-dependent tumor suppression and systemic inflammation.

Original languageEnglish (US)
Pages (from-to)e2123202119
JournalProceedings of the National Academy of Sciences of the United States of America
Volume119
Issue number22
DOIs
StatePublished - May 31 2022
Externally publishedYes

Keywords

  • Notch1 pathway
  • p53 family
  • p73
  • p73 C-terminal isoforms
  • tumor suppressor

ASJC Scopus subject areas

  • General

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