Paclitaxel, 5-fluorouracil, and folinic acid in metastatic breast cancer: BRE-26, a phase II trial.

D. H. Johnson, D. Paul, K. R. Hande

Research output: Contribution to journalArticle

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Abstract

5-Fluorouracil plus folinic acid and paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) are effective salvage therapies for metastatic breast cancer patients. Paclitaxel and 5-fluorouracil have additive cytotoxicity in MCF-7 cell lines. We performed a phase II trial of paclitaxel 175 mg/m2 over 3 hours on day I followed by folinic acid 300 mg over 1 hour before 5-fluorouracil 350 mg/m2 on days 1 to 3 every 28 days (TFL) in women with metastatic breast cancer. Analysis is reported on 37 patients with a minimum of 6 months follow-up who received a total of 192 cycles of TFL: nine cycles (5%) were associated with grade 3/4 neutropenia requiring hospitalization; seven (4%) cycles in two patients required granulocyte colony-stimulating factor due to neutropenia; no patient required platelet transfusions. Grade 3/4 nonhematologic toxicities were uncommon. Among the 34 patients evaluable for response, there were three complete responses (9%) and 18 partial responses (53%) for an overall response rate of 62%. Of the 19 evaluable patients with prior doxorubicin exposure, 11 (58%) responded compared with nine of 15 (60%) without prior doxorubicin. Plasma paclitaxel concentrations were measured at the completion of paclitaxel infusion and at 24 hours in 19 patients. TFL is an active, well-tolerated regimen in metastatic breast cancer.

Original languageEnglish (US)
JournalSeminars in Oncology
Volume24
Issue number1 Suppl 3
StatePublished - Feb 1997

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Leucovorin
Paclitaxel
Fluorouracil
Breast Neoplasms
Neutropenia
Doxorubicin
Salvage Therapy
Platelet Transfusion
MCF-7 Cells
Granulocyte Colony-Stimulating Factor
Hospitalization
Cell Line

ASJC Scopus subject areas

  • Oncology

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Paclitaxel, 5-fluorouracil, and folinic acid in metastatic breast cancer : BRE-26, a phase II trial. / Johnson, D. H.; Paul, D.; Hande, K. R.

In: Seminars in Oncology, Vol. 24, No. 1 Suppl 3, 02.1997.

Research output: Contribution to journalArticle

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