TY - JOUR
T1 - Paclitaxel-eluting stents reduce neointimal hyperplasia compared to bare metal stents in saphenous vein grafts
T2 - Intravascular ultrasonography analysis of the SOS (Stenting Of Saphenous Vein Grafts) trial
AU - Jeroudi, Omar M.
AU - Abdel-Karim, Abdul Rahman R
AU - Michael, Tesfaldet T.
AU - Lichtenwalter, Christopher
AU - de Lemos, James A
AU - Obel, Owen
AU - Addo, Tayo A
AU - Roesle, Michele
AU - Haagen, Donald
AU - Rangan, Bavana Venkata
AU - Raghunathan, Deepa
AU - DaSilva, Monica
AU - Saeed, Bilal
AU - Bissett, Joseph K.
AU - Sachdeva, Rajesh
AU - Voudris, Vassilios V.
AU - Karyofillis, Panagiotis
AU - Kar, Biswajit
AU - Rossen, James
AU - Fasseas, Panayotis
AU - Berger, Peter
AU - Banerjee, Subhash
AU - Brilakis, Emmanouil S
PY - 2011/12
Y1 - 2011/12
N2 - Aims: To compare the intravascular ultrasonography (IVUS) findings between saphenous vein grafts (SVG) treated with paclitaxel-eluting stents (PES) vs. bare metal stents (BMS) in the Stenting Of Saphenous Vein Grafts (SOS) trial.Methods and results: Of the 80 SOS trial patients, 38 had both baseline and follow-up IVUS examination and were included in this substudy: 17 patients received 28 BMS in 26 lesions and 21 patients received 30 PES in 28 lesions. Quantitative IVUS analysis was performed to determine the volume of in-stent neointimal hyperplasia (NIH) - defined as the difference between stent volume and lumen volume in the stented segments. Baseline characteristics were similar between patients who did and did not undergo baseline and follow-up IVUS. Patients receiving BMS and PES had similar stent and lumen volumes immediately after stenting. At 12-month follow-up, compared to BMS, PES-treated lesions had significantly less NIH volume (3.4 vs. 21.9 mm 3, p<0.001) and neointima hyperplasia progression (1.6 vs. 17.1 mm 3, p<0.001). No significant differences were seen in the 5 mm segment proximal and distal to the stent.Conclusions: Compared to BMS, use of PES in SVG lesions is associated with significantly lower NIH formation, which may help explain the improved clinical outcomes with PES in these lesions.
AB - Aims: To compare the intravascular ultrasonography (IVUS) findings between saphenous vein grafts (SVG) treated with paclitaxel-eluting stents (PES) vs. bare metal stents (BMS) in the Stenting Of Saphenous Vein Grafts (SOS) trial.Methods and results: Of the 80 SOS trial patients, 38 had both baseline and follow-up IVUS examination and were included in this substudy: 17 patients received 28 BMS in 26 lesions and 21 patients received 30 PES in 28 lesions. Quantitative IVUS analysis was performed to determine the volume of in-stent neointimal hyperplasia (NIH) - defined as the difference between stent volume and lumen volume in the stented segments. Baseline characteristics were similar between patients who did and did not undergo baseline and follow-up IVUS. Patients receiving BMS and PES had similar stent and lumen volumes immediately after stenting. At 12-month follow-up, compared to BMS, PES-treated lesions had significantly less NIH volume (3.4 vs. 21.9 mm 3, p<0.001) and neointima hyperplasia progression (1.6 vs. 17.1 mm 3, p<0.001). No significant differences were seen in the 5 mm segment proximal and distal to the stent.Conclusions: Compared to BMS, use of PES in SVG lesions is associated with significantly lower NIH formation, which may help explain the improved clinical outcomes with PES in these lesions.
KW - Intravascular ultrasonography
KW - Neointimal hyperplasia
KW - Paclitaxel-eluting stent
KW - Saphenous vein graft
UR - http://www.scopus.com/inward/record.url?scp=84855395954&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84855395954&partnerID=8YFLogxK
U2 - 10.4244/EIJV7I8A150
DO - 10.4244/EIJV7I8A150
M3 - Article
C2 - 22157480
AN - SCOPUS:84855395954
SN - 1774-024X
VL - 7
SP - 948
EP - 954
JO - EuroIntervention
JF - EuroIntervention
IS - 8
ER -