Paclitaxel-eluting stents reduce neointimal hyperplasia compared to bare metal stents in saphenous vein grafts: Intravascular ultrasonography analysis of the SOS (Stenting Of Saphenous Vein Grafts) trial

Omar M. Jeroudi, Abdul Rahman R Abdel-Karim, Tesfaldet T. Michael, Christopher Lichtenwalter, James A de Lemos, Owen Obel, Tayo A Addo, Michele Roesle, Donald Haagen, Bavana Venkata Rangan, Deepa Raghunathan, Monica DaSilva, Bilal Saeed, Joseph K. Bissett, Rajesh Sachdeva, Vassilios V. Voudris, Panagiotis Karyofillis, Biswajit Kar, James Rossen, Panayotis FasseasPeter Berger, Subhash Banerjee, Emmanouil S Brilakis

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Aims: To compare the intravascular ultrasonography (IVUS) findings between saphenous vein grafts (SVG) treated with paclitaxel-eluting stents (PES) vs. bare metal stents (BMS) in the Stenting Of Saphenous Vein Grafts (SOS) trial.Methods and results: Of the 80 SOS trial patients, 38 had both baseline and follow-up IVUS examination and were included in this substudy: 17 patients received 28 BMS in 26 lesions and 21 patients received 30 PES in 28 lesions. Quantitative IVUS analysis was performed to determine the volume of in-stent neointimal hyperplasia (NIH) - defined as the difference between stent volume and lumen volume in the stented segments. Baseline characteristics were similar between patients who did and did not undergo baseline and follow-up IVUS. Patients receiving BMS and PES had similar stent and lumen volumes immediately after stenting. At 12-month follow-up, compared to BMS, PES-treated lesions had significantly less NIH volume (3.4 vs. 21.9 mm 3, p<0.001) and neointima hyperplasia progression (1.6 vs. 17.1 mm 3, p<0.001). No significant differences were seen in the 5 mm segment proximal and distal to the stent.Conclusions: Compared to BMS, use of PES in SVG lesions is associated with significantly lower NIH formation, which may help explain the improved clinical outcomes with PES in these lesions.

Original languageEnglish (US)
Pages (from-to)948-954
Number of pages7
JournalEuroIntervention
Volume7
Issue number8
DOIs
StatePublished - Dec 1 2011

Keywords

  • Intravascular ultrasonography
  • Neointimal hyperplasia
  • Paclitaxel-eluting stent
  • Saphenous vein graft

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Jeroudi, O. M., Abdel-Karim, A. R. R., Michael, T. T., Lichtenwalter, C., de Lemos, J. A., Obel, O., Addo, T. A., Roesle, M., Haagen, D., Rangan, B. V., Raghunathan, D., DaSilva, M., Saeed, B., Bissett, J. K., Sachdeva, R., Voudris, V. V., Karyofillis, P., Kar, B., Rossen, J., ... Brilakis, E. S. (2011). Paclitaxel-eluting stents reduce neointimal hyperplasia compared to bare metal stents in saphenous vein grafts: Intravascular ultrasonography analysis of the SOS (Stenting Of Saphenous Vein Grafts) trial. EuroIntervention, 7(8), 948-954. https://doi.org/10.4244/EIJV7I8A150