Abstract
Management of paediatric extracranial germ-cell tumours carries a unique set of challenges. Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age range and vary in site, histology, and clinical behaviour. Patients with germ-cell tumours are managed by a diverse array of specialists. Thus, staging, risk stratification, and treatment approaches for germ-cell tumours have evolved disparately along several trajectories. Paediatric germ-cell tumours differ from the adolescent and adult disease in many ways, leading to complexities in applying age-appropriate, evidence-based care. Suboptimal outcomes remain for several groups of patients, including adolescents, and patients with extragonadal tumours, high tumour markers at diagnosis, or platinum-resistant disease. Survivors have significant long-term toxicities. The challenge moving forward will be to translate new insights from molecular studies and collaborative clinical data into improved patient outcomes. Future trials will be characterised by improved risk-stratification systems, biomarkers for response and toxic effects, rational reduction of therapy for low-risk patients and novel approaches for poor-risk patients, and improved international collaboration across paediatric and adult cooperative research groups.
| Original language | English (US) |
|---|---|
| Pages (from-to) | e149-e162 |
| Journal | The Lancet Oncology |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2016 |
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ASJC Scopus subject areas
- Medicine(all)
- Oncology
Cite this
Paediatric extracranial germ-cell tumours. / Shaikh, Furqan; Murray, Matthew J.; Amatruda, James F.; Coleman, Nicholas; Nicholson, James C.; Hale, Juliet P.; Pashankar, Farzana; Stoneham, Sara J.; Poynter, Jenny N.; Olson, Thomas A.; Billmire, Deborah F.; Stark, Daniel; Rodriguez-Galindo, Carlos; Frazier, A. Lindsay.
In: The Lancet Oncology, Vol. 17, No. 4, 01.04.2016, p. e149-e162.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Paediatric extracranial germ-cell tumours
AU - Shaikh, Furqan
AU - Murray, Matthew J.
AU - Amatruda, James F.
AU - Coleman, Nicholas
AU - Nicholson, James C.
AU - Hale, Juliet P.
AU - Pashankar, Farzana
AU - Stoneham, Sara J.
AU - Poynter, Jenny N.
AU - Olson, Thomas A.
AU - Billmire, Deborah F.
AU - Stark, Daniel
AU - Rodriguez-Galindo, Carlos
AU - Frazier, A. Lindsay
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Management of paediatric extracranial germ-cell tumours carries a unique set of challenges. Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age range and vary in site, histology, and clinical behaviour. Patients with germ-cell tumours are managed by a diverse array of specialists. Thus, staging, risk stratification, and treatment approaches for germ-cell tumours have evolved disparately along several trajectories. Paediatric germ-cell tumours differ from the adolescent and adult disease in many ways, leading to complexities in applying age-appropriate, evidence-based care. Suboptimal outcomes remain for several groups of patients, including adolescents, and patients with extragonadal tumours, high tumour markers at diagnosis, or platinum-resistant disease. Survivors have significant long-term toxicities. The challenge moving forward will be to translate new insights from molecular studies and collaborative clinical data into improved patient outcomes. Future trials will be characterised by improved risk-stratification systems, biomarkers for response and toxic effects, rational reduction of therapy for low-risk patients and novel approaches for poor-risk patients, and improved international collaboration across paediatric and adult cooperative research groups.
AB - Management of paediatric extracranial germ-cell tumours carries a unique set of challenges. Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age range and vary in site, histology, and clinical behaviour. Patients with germ-cell tumours are managed by a diverse array of specialists. Thus, staging, risk stratification, and treatment approaches for germ-cell tumours have evolved disparately along several trajectories. Paediatric germ-cell tumours differ from the adolescent and adult disease in many ways, leading to complexities in applying age-appropriate, evidence-based care. Suboptimal outcomes remain for several groups of patients, including adolescents, and patients with extragonadal tumours, high tumour markers at diagnosis, or platinum-resistant disease. Survivors have significant long-term toxicities. The challenge moving forward will be to translate new insights from molecular studies and collaborative clinical data into improved patient outcomes. Future trials will be characterised by improved risk-stratification systems, biomarkers for response and toxic effects, rational reduction of therapy for low-risk patients and novel approaches for poor-risk patients, and improved international collaboration across paediatric and adult cooperative research groups.
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UR - http://www.scopus.com/inward/citedby.url?scp=84977556590&partnerID=8YFLogxK
U2 - 10.1016/S1470-2045(15)00545-8
DO - 10.1016/S1470-2045(15)00545-8
M3 - Review article
C2 - 27300675
AN - SCOPUS:84977556590
VL - 17
SP - e149-e162
JO - The Lancet Oncology
JF - The Lancet Oncology
SN - 1470-2045
IS - 4
ER -