TY - JOUR
T1 - Pain in depression
T2 - STAR*D study findings
AU - Husain, Mustafa M.
AU - Rush, A. John
AU - Trivedi, Madhukar H.
AU - McClintock, Shawn M.
AU - Wisniewski, Stephen R.
AU - Davis, Lori
AU - Luther, James F.
AU - Zisook, Sid
AU - Fava, Maurizio
N1 - Funding Information:
We would like to acknowledge the support of the Veterans Affairs Research and Development at participating Veterans Affairs medical centers. We thank Eric Nestler, M.D., Ph.D., Lou and Ellen McGinley Distinguished Professor and Chairman, Department of Psychiatry, University of Texas Southwestern Medical Center, for providing administrative support; Jon Kilner, M.S., M.A., for providing editorial support; and Fast Word Information Processing Inc. (Dallas, Texas, USA) for providing secretarial support.
Funding Information:
This project was made possible by federal funds from the National Institute of Mental Health, National Institutes of Health, under Contract N01MH90003, given to the University of Texas Southwestern Medical Center at Dallas (Principal Investigator: A.J. Rush). The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services; neither does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government.
PY - 2007/8
Y1 - 2007/8
N2 - Background: Pain complaints commonly accompany major depressive disorder (MDD). However, whether patients with MDD and pain complaints differ from those without pain complaints is not well studied. Objective: The objective of this study was to compare depressed outpatients with and those without current pain complaints in terms of sociodemographic, clinical, and presenting symptom features. Methods: The baseline clinical and sociodemographic data of a large representative outpatient sample with nonpsychotic MDD (n=3745) enrolled in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) study were collected. Baseline information on pain complaints was based on Item No. 25 (somatic pain) of the 30-item Inventory of Depressive Symptomatology-Clinician Rating (IDS-C30). Results: After adjusting for sex, depression severity (IDS-C30 less Item No. 25), and general medical comorbidities (as measured by the Cumulative Illness Rating Scale total score), we found clinically meaningful differences between patients with and those without pain complaints. Younger, African American, Hispanic, and less educated patients were more likely to report pain complaints. In addition, those with pain complaints were more likely to report anxious features with irritable mood, sympathetic nervous system arousal, and gastrointestinal problems as well as poorer quality of life. Neither a more chronic course of illness nor suicidal ideation was associated with pain. Conclusions: Pain complaints are common among outpatients with MDD and are associated with certain symptom features and poorer quality of life. However, the findings of this study suggest that depression accompanied by pain complaints does not increase the clinical psychiatric burden or chronicity of depression.
AB - Background: Pain complaints commonly accompany major depressive disorder (MDD). However, whether patients with MDD and pain complaints differ from those without pain complaints is not well studied. Objective: The objective of this study was to compare depressed outpatients with and those without current pain complaints in terms of sociodemographic, clinical, and presenting symptom features. Methods: The baseline clinical and sociodemographic data of a large representative outpatient sample with nonpsychotic MDD (n=3745) enrolled in the STAR*D (Sequenced Treatment Alternatives to Relieve Depression) study were collected. Baseline information on pain complaints was based on Item No. 25 (somatic pain) of the 30-item Inventory of Depressive Symptomatology-Clinician Rating (IDS-C30). Results: After adjusting for sex, depression severity (IDS-C30 less Item No. 25), and general medical comorbidities (as measured by the Cumulative Illness Rating Scale total score), we found clinically meaningful differences between patients with and those without pain complaints. Younger, African American, Hispanic, and less educated patients were more likely to report pain complaints. In addition, those with pain complaints were more likely to report anxious features with irritable mood, sympathetic nervous system arousal, and gastrointestinal problems as well as poorer quality of life. Neither a more chronic course of illness nor suicidal ideation was associated with pain. Conclusions: Pain complaints are common among outpatients with MDD and are associated with certain symptom features and poorer quality of life. However, the findings of this study suggest that depression accompanied by pain complaints does not increase the clinical psychiatric burden or chronicity of depression.
KW - Depression
KW - Depression subtypes
KW - General medical comorbidities
KW - Pain
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U2 - 10.1016/j.jpsychores.2007.02.009
DO - 10.1016/j.jpsychores.2007.02.009
M3 - Article
C2 - 17662746
AN - SCOPUS:34447616978
SN - 0022-3999
VL - 63
SP - 113
EP - 122
JO - Journal of Psychosomatic Research
JF - Journal of Psychosomatic Research
IS - 2
ER -