Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes

Michael K. Racke, Elliot M. Frohman, Teresa Frohman

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuropathic pain and other pain syndromes occur in the vast majority of patients with multiple sclerosis at some time during their disease course. Pain can become chronic and paroxysmal. In this review, we will utilize clinical vignettes to describe various pain syndromes associated with multiple sclerosis and their pathophysiology. These syndromes vary from central neuropathic pain or Lhermitte's phenomenon associated with central nervous system lesions to trigeminal neuralgia and optic neuritis pain associated with nerve lesions. Muscular pain can also arise due to spasticity. In addition, we will discuss strategies utilized to help patients manage these symptoms.

Original languageEnglish (US)
Article number799698
JournalFrontiers in Neurology
Volume12
DOIs
StatePublished - Jan 13 2022
Externally publishedYes

Keywords

  • diagnosis
  • multiple sclerosis
  • pain
  • pathophysiology
  • treatment

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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