Paired versus two-group experimental design for rheological studies of vocal fold tissues

Che Xu, Dateng Li, I-Fan T Mau, Elhum McPherson, Mindy Du, Song Zhang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Vibratory function of the vocal folds is largely determined by the rheological properties or viscoelastic shear properties of the vocal fold lamina propria. To date, investigation of the sample size estimation and statistical experimental design for vocal fold rheological studies is nonexistent. The current work provides the closed-form sample size formulas for two major study designs (i.e. paired and two-group designs) in vocal fold research. Our results demonstrated that the paired design could greatly increase the statistical power compared to the two-group design. By comparing the variance of estimated treatment effect, this study also confirms that ignoring within-subject and within-vocal fold correlations during rheological data analysis will likely increase type I errors. Finally, viscoelastic shear properties of intact and scarred rabbit vocal fold lamina propria were measured and used to illustrate theoretical findings in a realistic scenario and project sample size requirement for future studies.

Original languageEnglish (US)
JournalJournal of Biomechanics
DOIs
StateAccepted/In press - Jan 1 2018

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Vocal Cords
Design of experiments
Research Design
Tissue
Sample Size
Mucous Membrane
Rabbits
Research

Keywords

  • Mixed-effects model
  • Sample size
  • Soft tissue
  • Statistical efficiency
  • Viscoelastic shear properties

ASJC Scopus subject areas

  • Biophysics
  • Orthopedics and Sports Medicine
  • Biomedical Engineering
  • Rehabilitation

Cite this

Paired versus two-group experimental design for rheological studies of vocal fold tissues. / Xu, Che; Li, Dateng; Mau, I-Fan T; McPherson, Elhum; Du, Mindy; Zhang, Song.

In: Journal of Biomechanics, 01.01.2018.

Research output: Contribution to journalArticle

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