Abstract
Palladium catalyzed addition of certain carbon pronucleophiles 2 to conjugated enynes 1 afforded the corresponding allenes 3 in good to excellent yields. The most reactive methynes such as methylmalononitrile 2c enabled to undergo double addition leading to alkenes 4. Catalyst optimization supported Pd2(dba)3·CHCl3 - dppf combination as the best system among all catalysts tested. The plausible mechanisms for these catalytic reactions were proposed.
Original language | English (US) |
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Pages (from-to) | 9097-9106 |
Number of pages | 10 |
Journal | Tetrahedron |
Volume | 53 |
Issue number | 27 |
DOIs | |
State | Published - Jul 7 1997 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry