Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis

Zhou Li, Dmitri Chernyak, Vladimir Gevorgyan

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.

Original languageEnglish (US)
Pages (from-to)6056-6059
Number of pages4
JournalOrganic Letters
Volume14
Issue number23
DOIs
StatePublished - Dec 7 2012
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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