Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis

Zhou Li; Dmitri Chernyak; Vladimir Gevorgyan

doi:10.1021/ol302947r

Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis

Zhou Li, Dmitri Chernyak, Vladimir Gevorgyan

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61 Scopus citations

Abstract

An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.

Original language	English (US)
Pages (from-to)	6056-6059
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	23
DOIs	https://doi.org/10.1021/ol302947r
State	Published - Dec 7 2012
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol302947r

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title = "Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis",

abstract = "An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.",

author = "Zhou Li and Dmitri Chernyak and Vladimir Gevorgyan",

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T1 - Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis

AU - Li, Zhou

AU - Chernyak, Dmitri

AU - Gevorgyan, Vladimir

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Y1 - 2012/12/7

N2 - An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.

AB - An efficient synthesis of densely substituted 2-aroylindolizines via the palladium-catalyzed carbonylative cyclization/arylation is reported. This transformation proceeds via the 5-endo-dig cyclization of 2-propargylpyridine triggered by an aroyl Pd complex. It produced diversely substituted 2-aroylindolizines in good to excellent yields.

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Palladium-catalyzed carbonylative cyclization/arylation cascade for 2-aroylindolizine synthesis

Abstract

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