Palladium-catalyzed cross-benzannulation of aminoenynes with diynes. Highly regioselective synthesis of polysubstituted anilines

Shinichi Saito, Naoyuki Uchiyama, Vladimir Gevorgyan, Yoshinori Yamamoto

Research output: Contribution to journalArticle

30 Scopus citations


Polysubstituted anilines were prepared by the palladium-catalyzed cross- benzannulation of conjugated aminoenynes 1-4 with diynes 8. The reaction proceeded in a highly regioselective manner under mild conditions, and the anilines were obtained as single regioisomers. Our method complements the well-known precedures for the preparation of polysubstituted anilines which are widely used in organic synthesis.

Original languageEnglish (US)
Pages (from-to)4338-4341
Number of pages4
JournalJournal of Organic Chemistry
Issue number14
Publication statusPublished - Jul 14 2000
Externally publishedYes


ASJC Scopus subject areas

  • Organic Chemistry

Cite this