Palladium-catalyzed cross-benzannulation of aminoenynes with diynes. Highly regioselective synthesis of polysubstituted anilines

Shinichi Saito, Naoyuki Uchiyama, Vladimir Gevorgyan, Yoshinori Yamamoto

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Abstract

Polysubstituted anilines were prepared by the palladium-catalyzed cross- benzannulation of conjugated aminoenynes 1-4 with diynes 8. The reaction proceeded in a highly regioselective manner under mild conditions, and the anilines were obtained as single regioisomers. Our method complements the well-known precedures for the preparation of polysubstituted anilines which are widely used in organic synthesis.

Original languageEnglish (US)
Pages (from-to)4338-4341
Number of pages4
JournalJournal of Organic Chemistry
Volume65
Issue number14
DOIs
Publication statusPublished - Jul 14 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Organic Chemistry

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