An efficient palladium-catalyzed intramolecular carbopalladation/ cyclization cascade toward tetra- and pentacyclic N-fused heterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with internal propargylic esters or ethers followed by the 5-endo-dig cyclization leading to polycyclic pyrroloheterocycles in moderate to excellent yields.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry