Palladium-catalyzed intramolecular carbopalladation/cyclization cascade: Access to polycyclic N-fused heterocycles

Dmitri Chernyak, Vladimir Gevorgyan

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

An efficient palladium-catalyzed intramolecular carbopalladation/ cyclization cascade toward tetra- and pentacyclic N-fused heterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with internal propargylic esters or ethers followed by the 5-endo-dig cyclization leading to polycyclic pyrroloheterocycles in moderate to excellent yields.

Original languageEnglish (US)
Pages (from-to)5558-5560
Number of pages3
JournalOrganic Letters
Volume12
Issue number23
DOIs
Publication statusPublished - Dec 3 2010
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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