Abstract
An efficient palladium-catalyzed intramolecular carbopalladation/ cyclization cascade toward tetra- and pentacyclic N-fused heterocycles has been developed. This transformation proceeds via the palladium-catalyzed coupling of aryl halides with internal propargylic esters or ethers followed by the 5-endo-dig cyclization leading to polycyclic pyrroloheterocycles in moderate to excellent yields.
Original language | English (US) |
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Pages (from-to) | 5558-5560 |
Number of pages | 3 |
Journal | Organic Letters |
Volume | 12 |
Issue number | 23 |
DOIs | |
State | Published - Dec 3 2010 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry