Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum

Jaime H. Noguez, Thushara K K Diyabalanage, Yoshinari Miyata, Xiao Song Xie, Frederick A. Valeriote, Charles D. Amsler, James B. McClintock, Bill J. Baker

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Palmerolides D-G are new bioactive macrolides isolated from the Antarctic tunicate Synoicum adareanum and are related to the melanoma-selective cytotoxin palmerolide A. Most of these palmerolides are potent V-ATPase inhibitors and have sub-micromolar activity against melanoma. Though palmerolide A remains the most potent of this series of natural products against mammalian V-ATPase, recent data suggests that palmerolide D is the most potent against melanoma. A comparison of the bioactivity data obtained for these natural product palmerolides has provided insight into the substructures necessary to retain V-ATPase inhibition and cytotoxic activity.

Original languageEnglish (US)
Pages (from-to)6608-6614
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume19
Issue number22
DOIs
StatePublished - Nov 15 2011

Fingerprint

Urochordata
Macrolides
Adenosine Triphosphatases
Melanoma
Biological Products
Cytotoxins
Bioactivity
palmerolide A

Keywords

  • Melanoma
  • Polyketide
  • V-ATPase inhibitor

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Noguez, J. H., Diyabalanage, T. K. K., Miyata, Y., Xie, X. S., Valeriote, F. A., Amsler, C. D., ... Baker, B. J. (2011). Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. Bioorganic and Medicinal Chemistry, 19(22), 6608-6614. https://doi.org/10.1016/j.bmc.2011.06.004

Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. / Noguez, Jaime H.; Diyabalanage, Thushara K K; Miyata, Yoshinari; Xie, Xiao Song; Valeriote, Frederick A.; Amsler, Charles D.; McClintock, James B.; Baker, Bill J.

In: Bioorganic and Medicinal Chemistry, Vol. 19, No. 22, 15.11.2011, p. 6608-6614.

Research output: Contribution to journalArticle

Noguez, JH, Diyabalanage, TKK, Miyata, Y, Xie, XS, Valeriote, FA, Amsler, CD, McClintock, JB & Baker, BJ 2011, 'Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum', Bioorganic and Medicinal Chemistry, vol. 19, no. 22, pp. 6608-6614. https://doi.org/10.1016/j.bmc.2011.06.004
Noguez JH, Diyabalanage TKK, Miyata Y, Xie XS, Valeriote FA, Amsler CD et al. Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. Bioorganic and Medicinal Chemistry. 2011 Nov 15;19(22):6608-6614. https://doi.org/10.1016/j.bmc.2011.06.004
Noguez, Jaime H. ; Diyabalanage, Thushara K K ; Miyata, Yoshinari ; Xie, Xiao Song ; Valeriote, Frederick A. ; Amsler, Charles D. ; McClintock, James B. ; Baker, Bill J. / Palmerolide macrolides from the Antarctic tunicate Synoicum adareanum. In: Bioorganic and Medicinal Chemistry. 2011 ; Vol. 19, No. 22. pp. 6608-6614.
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