Palmitoylated Proteins in Dendritic Spine Remodeling

Research output: Contribution to journalReview articlepeer-review

Abstract

Activity-responsive changes in the actin cytoskeleton are required for the biogenesis, motility, and remodeling of dendritic spines. These changes are governed by proteins that regulate the polymerization, depolymerization, bundling, and branching of actin filaments. Thus, processes that have been extensively characterized in the context of non-neuronal cell shape change and migration are also critical for learning and memory. In this review article, we highlight actin regulatory proteins that associate, at least transiently, with the dendritic plasma membrane. All of these proteins have been shown, either in directed studies or in high—throughput screens, to undergo palmitoylation, a potentially reversible, and stimulus-dependent cysteine modification. Palmitoylation increases the affinity of peripheral proteins for the membrane bilayer and contributes to their subcellular localization and recruitment to cholesterol-rich membrane microdomains.

Original languageEnglish (US)
Article number22
JournalFrontiers in Synaptic Neuroscience
Volume12
DOIs
StatePublished - Jun 16 2020

Keywords

  • actin assembly
  • cytoskeletal remodeling
  • dendritic spines
  • palmitoylation
  • synaptic plasticity

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cell Biology

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