Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROMEII criteria for irritable bowel syndrome

Piero Portincasa, Antonio Moschetta, Giuseppe Baldassare, Donato F. Altomare, Giuseppe Palasciano

Research output: Contribution to journalArticle

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Abstract

Aim: Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern Italy. Methods: One hundred IBS patients (F:M=73:27, age 48±2 years, mean±SE) fulfilling ROME II criteria matched with 100 healthy subjects (F:M=70:30,45±2 years). Dyspepsia, bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT) were measured respectively by ultrasonography and H2-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/discomfort were monitored using visual-analogue scales. Results: Compared with controls, IBS patients had increased dyspepsia (score 12.6±0.7 vs 5.1±0.2, P<0.0001), weekly bowel movements (12.3±0.4 vs 5.5±0.2, P?<0.00001, comparable stool shape), alexithymia (score 59.1±1.1 vs 40.5±1.0, P=0.001), poor quality of life and psycho-affective profile. IBS patients had normal gallbladder emptying, but delayed gastric emptying (T50: 35.5±1.0 vs 26.1±0.6 min, P=0.00001) and OCTT (163.0±5.4 vs 96.6±1.8 min, P=0.00001). Fullness, nausea, and epigastric pain/discomfort were greater in IBS than in controls. Conclusion: ROME II IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of life. The presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recoveed after therapy.

Original languageEnglish (US)
Pages (from-to)2293-2299
Number of pages7
JournalWorld Journal of Gastroenterology
Volume9
Issue number10
StatePublished - Oct 2003

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Affective Symptoms
Group Processes
Irritable Bowel Syndrome
Quality of Life
Dyspepsia
Psychology
Nausea
Gallbladder Emptying
Sensation Disorders
Pain
Breath Tests
Gastrointestinal Motility
Gastric Emptying
Appetite
Gallbladder
Visual Analog Scale
Italy
Habits
Intestines
Meals

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROMEII criteria for irritable bowel syndrome. / Portincasa, Piero; Moschetta, Antonio; Baldassare, Giuseppe; Altomare, Donato F.; Palasciano, Giuseppe.

In: World Journal of Gastroenterology, Vol. 9, No. 10, 10.2003, p. 2293-2299.

Research output: Contribution to journalArticle

Portincasa, Piero ; Moschetta, Antonio ; Baldassare, Giuseppe ; Altomare, Donato F. ; Palasciano, Giuseppe. / Pan-enteric dysmotility, impaired quality of life and alexithymia in a large group of patients meeting ROMEII criteria for irritable bowel syndrome. In: World Journal of Gastroenterology. 2003 ; Vol. 9, No. 10. pp. 2293-2299.
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abstract = "Aim: Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern Italy. Methods: One hundred IBS patients (F:M=73:27, age 48±2 years, mean±SE) fulfilling ROME II criteria matched with 100 healthy subjects (F:M=70:30,45±2 years). Dyspepsia, bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT) were measured respectively by ultrasonography and H2-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/discomfort were monitored using visual-analogue scales. Results: Compared with controls, IBS patients had increased dyspepsia (score 12.6±0.7 vs 5.1±0.2, P<0.0001), weekly bowel movements (12.3±0.4 vs 5.5±0.2, P?<0.00001, comparable stool shape), alexithymia (score 59.1±1.1 vs 40.5±1.0, P=0.001), poor quality of life and psycho-affective profile. IBS patients had normal gallbladder emptying, but delayed gastric emptying (T50: 35.5±1.0 vs 26.1±0.6 min, P=0.00001) and OCTT (163.0±5.4 vs 96.6±1.8 min, P=0.00001). Fullness, nausea, and epigastric pain/discomfort were greater in IBS than in controls. Conclusion: ROME II IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of life. The presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recoveed after therapy.",
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AU - Altomare, Donato F.

AU - Palasciano, Giuseppe

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N2 - Aim: Psychological factors, altered motility and sensation disorders of the intestine can be variably associated with irritable bowel syndrome (IBS). Such aspects have not been investigated simultaneously. The aim of this paper was to evaluate gastrointestinal motility and symptoms, psychological spectrum and quality of life in a large group of IBS patients in southern Italy. Methods: One hundred IBS patients (F:M=73:27, age 48±2 years, mean±SE) fulfilling ROME II criteria matched with 100 healthy subjects (F:M=70:30,45±2 years). Dyspepsia, bowel habit, alexithymia, psycho-affective profile and quality of life were assessed using specific questionnaires. Basally and postprandially, changes in gallbladder volumes and antral areas after liquid meal and orocaecal transit time (OCTT) were measured respectively by ultrasonography and H2-breath test. Appetite, satiety, fullness, nausea, and epigastric pain/discomfort were monitored using visual-analogue scales. Results: Compared with controls, IBS patients had increased dyspepsia (score 12.6±0.7 vs 5.1±0.2, P<0.0001), weekly bowel movements (12.3±0.4 vs 5.5±0.2, P?<0.00001, comparable stool shape), alexithymia (score 59.1±1.1 vs 40.5±1.0, P=0.001), poor quality of life and psycho-affective profile. IBS patients had normal gallbladder emptying, but delayed gastric emptying (T50: 35.5±1.0 vs 26.1±0.6 min, P=0.00001) and OCTT (163.0±5.4 vs 96.6±1.8 min, P=0.00001). Fullness, nausea, and epigastric pain/discomfort were greater in IBS than in controls. Conclusion: ROME II IBS patients have a pan-enteric dysmotility with frequent dyspepsia, associated with psychological morbidity and greatly impaired quality of life. The presence of alexithymia, a stable trait, is a novel finding of potential interest to detect subgroups of IBS patients with different patterns recoveed after therapy.

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