Pancreas-kidney transplantation is associated with reduced fracture risk compared with kidney-alone transplantation in men with type 1 diabetes

Lucas E. Nikkel, Sapna P. Iyer, Sumit Mohan, Amy Zhang, Donald J. Mcmahon, Bekir Tanriover, David J. Cohen, Lloyd Ratner, Christopher S. Hollenbeak, Mishaela R. Rubin, Elizabeth Shane, Thomas L. Nickolas

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Both type 1 diabetes mellitus and end-stage renal disease are associated with increased fracture risk, likely because of metabolic abnormalities that reduce bone strength. Simultaneous pancreas-kidney transplantation is a treatment of choice for patients with both disorders, yet the effects of simultaneous pancreas-kidney and kidney transplantation alone on post-transplantation fracture risk are unknown. From the United States Renal Data System, we identified 11,145 adults with type 1 diabetes undergoing transplantation, of whom 4933 had a simultaneous pancreas-kidney transplant and 6212 had a kidney-alone transplant between 2000 and 2006. Post-transplantation fractures resulting in hospitalization were identified from discharge codes. Time to first fracture was modeled and propensity score adjustment was used to balance covariates between groups. Fractures occurred in significantly fewer (4.7%) of pancreas-kidney compared with kidney-alone transplant (5.9%) cohorts. After gender stratification and adjustment for fracture covariates, pancreas-kidney transplantation was associated with a significant 31% reduction in fracture risk in men (hazard risk 0.69). Older age, white race, prior dialysis, and pre-transplantation fracture were also associated with increased fracture risk. Prospective studies are needed to determine the gender-specific mechanisms by which pancreas-kidney transplantation reduces fracture risk in men.

Original languageEnglish (US)
Pages (from-to)471-478
Number of pages8
JournalKidney International
Volume83
Issue number3
DOIs
StatePublished - Mar 2013

Fingerprint

Pancreas Transplantation
Type 1 Diabetes Mellitus
Kidney Transplantation
Kidney
Transplantation
Pancreas
Transplants
Fracture Fixation
Propensity Score
Information Systems
Chronic Kidney Failure
Dialysis
Hospitalization
Prospective Studies
Bone and Bones

Keywords

  • diabetes
  • fracture
  • renal
  • transplantation
  • USRDS

ASJC Scopus subject areas

  • Nephrology

Cite this

Pancreas-kidney transplantation is associated with reduced fracture risk compared with kidney-alone transplantation in men with type 1 diabetes. / Nikkel, Lucas E.; Iyer, Sapna P.; Mohan, Sumit; Zhang, Amy; Mcmahon, Donald J.; Tanriover, Bekir; Cohen, David J.; Ratner, Lloyd; Hollenbeak, Christopher S.; Rubin, Mishaela R.; Shane, Elizabeth; Nickolas, Thomas L.

In: Kidney International, Vol. 83, No. 3, 03.2013, p. 471-478.

Research output: Contribution to journalArticle

Nikkel, LE, Iyer, SP, Mohan, S, Zhang, A, Mcmahon, DJ, Tanriover, B, Cohen, DJ, Ratner, L, Hollenbeak, CS, Rubin, MR, Shane, E & Nickolas, TL 2013, 'Pancreas-kidney transplantation is associated with reduced fracture risk compared with kidney-alone transplantation in men with type 1 diabetes', Kidney International, vol. 83, no. 3, pp. 471-478. https://doi.org/10.1038/ki.2012.430
Nikkel, Lucas E. ; Iyer, Sapna P. ; Mohan, Sumit ; Zhang, Amy ; Mcmahon, Donald J. ; Tanriover, Bekir ; Cohen, David J. ; Ratner, Lloyd ; Hollenbeak, Christopher S. ; Rubin, Mishaela R. ; Shane, Elizabeth ; Nickolas, Thomas L. / Pancreas-kidney transplantation is associated with reduced fracture risk compared with kidney-alone transplantation in men with type 1 diabetes. In: Kidney International. 2013 ; Vol. 83, No. 3. pp. 471-478.
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