Pancreatic Alpha-Cell Function in Trauma

A. Lindsey, Fausto Santeusanio, Jan Braaten, Gerald R. Faloona, Roger H Unger

Research output: Contribution to journalArticlepeer-review

86 Scopus citations


In a group of 20 consecutive patients hospitalized with severe traumatic shock, mean plasma glucagon levels averaged 328±65μμg/ml, significantly above the normal fasting levels. Insulin concentration was normal, and plasma glucose levels averaged 188 (±14) mg/100 ml, significantly above normal. Insulin-glucagon molar ratio was low in 17 of the 20 patients. In three patients undergoing major surgery without associated hypotension, glucagon concentrations did not rise comparably. Hyperglucagonemia without a proportional rise in insulin may be the usual islet cell response to severe trauma and possibly could contribute to survival.

Original languageEnglish (US)
Pages (from-to)757-761
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Issue number7
StatePublished - Feb 18 1974

ASJC Scopus subject areas

  • Medicine(all)


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