TY - JOUR
T1 - Pancreatic Alpha-Cell Function in Trauma
AU - Lindsey, A.
AU - Santeusanio, Fausto
AU - Braaten, Jan
AU - Faloona, Gerald R.
AU - Unger, Roger H
PY - 1974/2/18
Y1 - 1974/2/18
N2 - In a group of 20 consecutive patients hospitalized with severe traumatic shock, mean plasma glucagon levels averaged 328±65μμg/ml, significantly above the normal fasting levels. Insulin concentration was normal, and plasma glucose levels averaged 188 (±14) mg/100 ml, significantly above normal. Insulin-glucagon molar ratio was low in 17 of the 20 patients. In three patients undergoing major surgery without associated hypotension, glucagon concentrations did not rise comparably. Hyperglucagonemia without a proportional rise in insulin may be the usual islet cell response to severe trauma and possibly could contribute to survival.
AB - In a group of 20 consecutive patients hospitalized with severe traumatic shock, mean plasma glucagon levels averaged 328±65μμg/ml, significantly above the normal fasting levels. Insulin concentration was normal, and plasma glucose levels averaged 188 (±14) mg/100 ml, significantly above normal. Insulin-glucagon molar ratio was low in 17 of the 20 patients. In three patients undergoing major surgery without associated hypotension, glucagon concentrations did not rise comparably. Hyperglucagonemia without a proportional rise in insulin may be the usual islet cell response to severe trauma and possibly could contribute to survival.
UR - http://www.scopus.com/inward/record.url?scp=84947510314&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947510314&partnerID=8YFLogxK
U2 - 10.1001/jama.1974.03230200015003
DO - 10.1001/jama.1974.03230200015003
M3 - Article
C2 - 4590022
AN - SCOPUS:84947510314
SN - 0098-7484
VL - 227
SP - 757
EP - 761
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 7
ER -