Pancreatic cancer stem cells: Fact or fiction?

Vikash J. Bhagwandin, Jerry W. Shay

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.

Original languageEnglish (US)
Pages (from-to)248-259
Number of pages12
JournalBiochimica et Biophysica Acta - Molecular Basis of Disease
Volume1792
Issue number4
DOIs
StatePublished - Apr 1 2009

Keywords

  • Cancer stem cell model
  • EMT
  • Gemcitabine
  • Label retaining cell
  • Metastasis
  • Multidrug resistance
  • Pancreatic cancer
  • Side population
  • Stem cell
  • Telomerase

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology

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