Pancreatic cancer stem cells: Fact or fiction?

Vikash J. Bhagwandin; Jerry W. Shay

doi:10.1016/j.bbadis.2009.02.007

Pancreatic cancer stem cells: Fact or fiction?

Vikash J. Bhagwandin, Jerry W. Shay

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.

Original language	English (US)
Pages (from-to)	248-259
Number of pages	12
Journal	Biochimica et Biophysica Acta - Molecular Basis of Disease
Volume	1792
Issue number	4
DOIs	https://doi.org/10.1016/j.bbadis.2009.02.007
State	Published - Apr 2009

Keywords

Cancer stem cell model
EMT
Gemcitabine
Label retaining cell
Metastasis
Multidrug resistance
Pancreatic cancer
Side population
Stem cell
Telomerase

ASJC Scopus subject areas

Molecular Medicine
Molecular Biology

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10.1016/j.bbadis.2009.02.007

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title = "Pancreatic cancer stem cells: Fact or fiction?",

abstract = "The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.",

keywords = "Cancer stem cell model, EMT, Gemcitabine, Label retaining cell, Metastasis, Multidrug resistance, Pancreatic cancer, Side population, Stem cell, Telomerase",

author = "Bhagwandin, {Vikash J.} and Shay, {Jerry W.}",

note = "Funding Information: We thank Geron Corporation (Menlo Park, CA) for providing the GRN163L reagent and the NCI SPORE in Gastrointestinal Cancer Grant P50CA12729701 for financial support.",

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AU - Bhagwandin, Vikash J.

AU - Shay, Jerry W.

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AB - The terms cancer-initiating or cancer stem cells have been the subject of great interest in recent years. In this review we will use pancreatic cancer as an overall theme to draw parallels with historical findings to compare to recent reports of stem-like characteristics in pancreatic cancer. We will cover such topics as label-retaining cells (side-population), ABC transporter pumps, telomerase, quiescence, cell surface stem cell markers, and epithelial-mesenchymal transitions. Finally we will integrate the available findings into a pancreatic stem cell model that also includes metastatic disease.

KW - Cancer stem cell model

KW - EMT

KW - Gemcitabine

KW - Label retaining cell

KW - Metastasis

KW - Multidrug resistance

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Pancreatic cancer stem cells: Fact or fiction?

Abstract

Keywords

ASJC Scopus subject areas

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