Pancreatic Islets Regeneration. The Bioengineering Approach.

Timil Patel, Marcus Salvatori, Sij Hemal, Andrea Peloso, Ravi Katari, Joao Paulo Zambon, Shay Soker, Giuseppe Orlando

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Diabetes mellitus is a major cause of mortality around the world. In fact, the International Diabetes Foundation projects 438 million individuals worldwide will have diabetes by the year 2030. Unfortunately, the treatment of diabetes is not adequate. Standard medical treatment through dietary modification, increased physical activity, medications, and exogenous insulin can undoubtedly reduce the microvascular and macrovascular complications of diabetes. However, even if all standard medical approaches are diligently followed, one cannot confidently eliminate the potential health complications from diabetes. Although allogenic transplantation is the only restorative treatment, issues with donor shortages and lifelong immunosuppression hinder meaningful clinical application. Pioneering technologies in regenerative medicine and tissue engineering, however, aim to overcome these current limitations. Novel bioengineering techniques, such as islet encapsulation, decellularization-recellularization and a growing appreciation of using native extracellular matrix as a scaffold for regeneration offers tremendous promise to ultimately bioengineer a functional pancreas capable of curing insulin-dependent diabetes.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine Applications in Organ Transplantation
PublisherElsevier Inc.
Pages599-607
Number of pages9
ISBN (Print)9780123985231
DOIs
StatePublished - Jan 1 2014

Keywords

  • Decellularization-recellularization
  • Extracellular matrix
  • Islet encapsulation
  • Pancreatic transplantation
  • Whole-organ pancreas bioengineering

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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