Pancreatic microcirculation in acute pancreatitis

Makoto Sunamura, Jun Ichiro Yamauchi, Kazuhiko Shibuya, Hang Ming Chen, Lianghao Ding, Kazunori Takeda, Masao Kobari, Seiki Matsuno

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

We present a review of the microvascular morphology of the pancreas and microstructure of the pancreatic lobule, and report our experimental results of the investigation of pancreatic microcirculation following acute pancreatitis. Impairment of pancreatic microcirculation in the early phase of acute pancreatitis may play a key role in the progression of this disease. Possible contributory mechanisms include increased vascular permeability, reduced blood flow, leukocyte-endothelial cell interaction and intravascular thrombus formation. Using an in-vivo microscope system and off-line computer analysis, we achieved direct visualization and quantification of changes in microvascular permeability and leukocyte behavior in pancreas with acute pancreatitis. Bradykinin and oxygen radicals have been demonstrated to be involved in the increase of vascular permeability in the early stage of caerulein pancreatitis. Leukocyte adherence to the vessels in the pancreatic microcirculation is a secondary event following permeability changes in acute pancreatitis. Leukocyte infiltration during exacerbation of acute pancreatitis is mediated by leukocyte-endothelial cell interaction via leukocyte integrin CD11b/18.

Original languageEnglish (US)
Pages (from-to)62-68
Number of pages7
JournalJournal of Hepato-Biliary-Pancreatic Surgery
Volume5
Issue number1
DOIs
StatePublished - Jan 1 1998

Keywords

  • Acute pancreatitis
  • Leukocyte endothelial cell interaction
  • Pancreatic microcirculation
  • Permeability
  • Vital microscopy

ASJC Scopus subject areas

  • Surgery
  • Hepatology

Fingerprint Dive into the research topics of 'Pancreatic microcirculation in acute pancreatitis'. Together they form a unique fingerprint.

  • Cite this

    Sunamura, M., Yamauchi, J. I., Shibuya, K., Chen, H. M., Ding, L., Takeda, K., Kobari, M., & Matsuno, S. (1998). Pancreatic microcirculation in acute pancreatitis. Journal of Hepato-Biliary-Pancreatic Surgery, 5(1), 62-68. https://doi.org/10.1007/PL00009952