Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats

E. Zyznar; V. Schusdziarra; Roger H Unger

doi:10.1016/0024-3205(79)90056-0

Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats

E. Zyznar, V. Schusdziarra, Roger H Unger

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Somatostatin-like immunoreactivity (SLI) was extracted from the canine pancreas and purified by ion exchange, affinity chromatography and gel filtration. The 1600 dalton fraction, which is physicochemically similar to synthetic somatostatin was infused into the peripheral circulation of anesthetized rats and its effect upon gastric acid secretion was compared with that of synthetic somatostatin. Both synthetic somatostatin and pancreatic SLI in a dose of 7-8 μg/kg/h suppressed pentagastrin-stimulated gastric acid secretion. It is concluded that the highly purified 1600 dalton fraction of canine pancreatic SLI, like synthetic somatostatin, can exert biological activity upon the stomach of rats.

Original language	English (US)
Pages (from-to)	1195-1199
Number of pages	5
Journal	Life Sciences
Volume	24
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(79)90056-0
State	Published - Mar 26 1979

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

Access to Document

10.1016/0024-3205(79)90056-0

Cite this

@article{a190a661c3d34e25bc03b69a029b0829,

title = "Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats",

abstract = "Somatostatin-like immunoreactivity (SLI) was extracted from the canine pancreas and purified by ion exchange, affinity chromatography and gel filtration. The 1600 dalton fraction, which is physicochemically similar to synthetic somatostatin was infused into the peripheral circulation of anesthetized rats and its effect upon gastric acid secretion was compared with that of synthetic somatostatin. Both synthetic somatostatin and pancreatic SLI in a dose of 7-8 μg/kg/h suppressed pentagastrin-stimulated gastric acid secretion. It is concluded that the highly purified 1600 dalton fraction of canine pancreatic SLI, like synthetic somatostatin, can exert biological activity upon the stomach of rats.",

author = "E. Zyznar and V. Schusdziarra and Unger, {Roger H}",

note = "Funding Information: This work was supported by VA Institutional Research Support Grant 549-8000-01 ; National Institutes of Health Grant AM 02700-16 and Contract NO1-AM-62219 ; and The Salk Institute - Texas Research Foundation .",

year = "1979",

month = mar,

day = "26",

doi = "10.1016/0024-3205(79)90056-0",

language = "English (US)",

volume = "24",

pages = "1195--1199",

journal = "Life Sciences",

issn = "0024-3205",

publisher = "Elsevier Inc.",

number = "13",

}

TY - JOUR

T1 - Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats

AU - Zyznar, E.

AU - Schusdziarra, V.

AU - Unger, Roger H

N1 - Funding Information: This work was supported by VA Institutional Research Support Grant 549-8000-01 ; National Institutes of Health Grant AM 02700-16 and Contract NO1-AM-62219 ; and The Salk Institute - Texas Research Foundation .

PY - 1979/3/26

Y1 - 1979/3/26

N2 - Somatostatin-like immunoreactivity (SLI) was extracted from the canine pancreas and purified by ion exchange, affinity chromatography and gel filtration. The 1600 dalton fraction, which is physicochemically similar to synthetic somatostatin was infused into the peripheral circulation of anesthetized rats and its effect upon gastric acid secretion was compared with that of synthetic somatostatin. Both synthetic somatostatin and pancreatic SLI in a dose of 7-8 μg/kg/h suppressed pentagastrin-stimulated gastric acid secretion. It is concluded that the highly purified 1600 dalton fraction of canine pancreatic SLI, like synthetic somatostatin, can exert biological activity upon the stomach of rats.

AB - Somatostatin-like immunoreactivity (SLI) was extracted from the canine pancreas and purified by ion exchange, affinity chromatography and gel filtration. The 1600 dalton fraction, which is physicochemically similar to synthetic somatostatin was infused into the peripheral circulation of anesthetized rats and its effect upon gastric acid secretion was compared with that of synthetic somatostatin. Both synthetic somatostatin and pancreatic SLI in a dose of 7-8 μg/kg/h suppressed pentagastrin-stimulated gastric acid secretion. It is concluded that the highly purified 1600 dalton fraction of canine pancreatic SLI, like synthetic somatostatin, can exert biological activity upon the stomach of rats.

UR - http://www.scopus.com/inward/record.url?scp=0018395708&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018395708&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(79)90056-0

DO - 10.1016/0024-3205(79)90056-0

M3 - Article

C2 - 449619

AN - SCOPUS:0018395708

SN - 0024-3205

VL - 24

SP - 1195

EP - 1199

JO - Life Sciences

JF - Life Sciences

IS - 13

ER -

Pancreatic somatostatin-like immunoreactivity suppresses gastric acid secretion in rats

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this