Pantoprazole maintenance therapy prevents relapse of erosive oesophagitis

D. C. Metz, W. J. Bochenek, Richard Aaronson, James L. Achord, Dennis Avner, Jose Behar, Mark Blitstein, Saul Feldman, Ralph A. Giannella, William V. Harford, Vernon Hee, James V. Jones, Peter J. Karras, David Kogut, Robert Kornfield, Thomas Kovacs, Thomas Meister, David Metz, Philip Miner, John OrchardDaniel Pambianco, Anirudh Rai, Richard Redinger, Dennis Riff, John Rodgers, Stanley Rosenberg, Alan Safdi, Paul Schlesinger, Howard I. Schwartz, William Snape, James Wagonfeld, Steven Wilkofsky, Barry D. Winston, Lawrence Wruble, Wallace Wu

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Objectives: To compare the safety and efficacy of pantoprazole with ranitidine for the maintenance of endoscopically documented healed (grade 0 or 1) erosive oesophagitis. Methods: Patients (371) were randomly assigned to receive pantoprazole 10, 20 or 40 mg or ranitidine 150 mg. Endoscopies were performed after 1, 3, 6 and 12 months or when symptoms suggesting relapse (grade = 2) developed. Gastric biopsies were obtained at baseline and on at least one postbaseline visit. Symptom-free days and Gelusil use were assessed. Results: Pantoprazole was significantly (P < 0.001) more effective in maintaining erosive oesophagitis healing. After 12 months. 33%, 40%, 68% and 82% of patients remained healed for the ranitidine and pantoprazole 10, 20 and 40 mg groups, respectively. Daytime and night-time heartburn were eliminated in > 90% of days for the pantoprazole 40 mg group. Gelusil use was significantly lower with pantoprazole 20 and 40 mg than with ranitidine (P < 0.02) during the first 9 months. Conclusions: Twelve months of maintenance therapy with pantoprazole (10-40 mg once daily) was superior to ranitidine (150 mg twice daily) in maintaining erosive oesophagitis healing. Pantoprazole 40 mg provided the most consistent efficacy and was well tolerated.

Original languageEnglish (US)
Pages (from-to)155-164
Number of pages10
JournalAlimentary Pharmacology and Therapeutics
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

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