Pantothenic acid

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Pantothenic acid is a water soluble B vitamin (vitamin B5) that is not synthesized by animals but is widely available in the diet. Pantothenic acid is metabolized to two important cofactors for enzymes: coenzyme A (CoA) and acyl carrier protein (ACP). Both cofactors contain a sulfhydryl group (–SH), which reacts with carboxylic acids to form thioesters. ACP has a central role in the synthesis of fatty acids. CoA forms thioesters with a very wide range of metabolic intermediates and has been estimated to be a cofactor for about 4% of all known enzymes.[1] It is also involved with fatty acid synthesis but has broader functions in fatty acid oxidation, ketone body metabolism, oxidative metabolism of pyruvate via pyruvate dehydrogenase and the citric acid cycle, and in the metabolism of a wide variety of organic acids, including those in catabolic pathways of amino acid metabolism.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Dietary Supplements
PublisherCRC Press
Pages517-525
Number of pages9
ISBN (Electronic)9781482204056
ISBN (Print)0824755049, 9780824755041
DOIs
StatePublished - Jan 1 2004
Externally publishedYes

ASJC Scopus subject areas

  • Health Professions(all)
  • Medicine(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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