TY - JOUR
T1 - PAQRs
T2 - A counteracting force to ceramides?
AU - Holland, William L.
AU - Scherer, Philipp E.
PY - 2009/4
Y1 - 2009/4
N2 - In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger.
AB - In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger.
UR - http://www.scopus.com/inward/record.url?scp=63849250388&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=63849250388&partnerID=8YFLogxK
U2 - 10.1124/mol.109.054817
DO - 10.1124/mol.109.054817
M3 - Review article
C2 - 19158359
AN - SCOPUS:63849250388
SN - 0026-895X
VL - 75
SP - 740
EP - 743
JO - Molecular Pharmacology
JF - Molecular Pharmacology
IS - 4
ER -