PAQRs: A counteracting force to ceramides?

William L. Holland, Philipp E. Scherer

Research output: Contribution to journalReview article

24 Scopus citations


In recent years, sphingolipids have garnered increasing attention for their roles in modulating intracellular signaling events. Circulating factors associated with obesity promote excess accumulation of ceramide or glucosylceramide derivatives, which impair insulin action in peripheral tissues. In this issue, Villa et al. (p. 866) provide evidence that, in yeast, the progestin and adipoQ receptor superfamily of receptors mediate their effects via a novel ceramidase activity, generating sphingoid base as a second messenger.

Original languageEnglish (US)
Pages (from-to)740-743
Number of pages4
JournalMolecular Pharmacology
Issue number4
StatePublished - Apr 1 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

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